Council of Scientific and Industrial Research

Other

Uttam Ramrao Kalkote

Subhash Prataprao Chavan

Rohini Ramesh Joshi

Mukund Keshao Gurjar

Digambar Vitthal Gokhale

Thottapillil Ravindranathan

Subhash Krishnaji Kamat

Sandeep Raghunath Ghorpade

Ravindranathan Thottapillil

Suresh Mahadev Kadam

Ramesh Anna Joshi

Sanjay Narayan Nene

Vithal Venkatrao Jogdand

Kulbhushan Balwant Bastawde

Bhaskar Ganapatrao Gaikwad

Shreerang V Joshi

Thottappillil Ravindranathan

Kamalam Balakrishnan

Latha Sivadasan

Sunil Ramchandra Bhide

Shamrao Ganapatrao Patil

Dushant Anandrao Khobragade

Mukund Keshav Gurjar

Nagaraj Ramanuj Ayyangar

Sanjay Janardhan Naik

Amar Gopal Chittiboyina

Vasant K Sharma

Thotapallil Ravindranathan

Harish Kashinath Mondkar

Kulbhussan Balwant Bastawade

Anil R Choudhary

Digamber Vitthal Gokhale

Kulbhushan Balwant Bastawade

Sandhya Suresh Sudge

The Present invention relates to a process for the preparation of (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine of formula 1.  (RS) 3-Methyl-1-(2-piperidinyl phenyl butyl amine having formula 1 is an important key intermediate for the synthesis of repaglinide of formula 2 an oral hypoglycemic agent. 

Process for preparing (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine

Process for the preparation of ethyl 3-ethoxy-4-ethoxycarbonyl-phenylacetate

Process for the preparation of 1-&lsqb;cyano(aryl)methyl&rsqb; cyclohexanol

A novel route has been developed for substituted 2-&lsqb;-6-benzyl-5-oxo-3-phenyl-(3s,7s,7aR)-perhydroimidazol&lsqb;1,5-c&rsqb;&lsqb;1,3&rsqb;thiazol&rsqb; compounds; crucial intermediates for D(&plus;)-biotin of formula (7) which involves simple, efficient, practical and cost effective protocol. These are crucial intermediates for commercially important D(&plus;)-biotin preparation. These compounds are more stable and are produced by non-hazardous methods.

Substituted 2-&lsqb;-6-benzyl-5-oxo-3-phenyl-(3s,7s, 7aR)-perhydroimidazol&lsqb;1,5-c&rsqb;&lsqb;1,3&rsqb;thiazol-7yl&rsqb; compounds

Process for the preparation of 4(R)-hydroxy cyclopent-2-en1(S)-acetate

The present invention relates to a process for the preparation of optically active 6-hydroxymethyl-4-(tert-butyldimethylsilyloxy)-(4R,6S)-tetrahydro-2H-2-pyranone(&bgr;-Hydroxy-&dgr;-lactone) an important intermediate in the synthesis of biologically active drugs e.g. compactin, atorvastatin, fluvastatin, cholesterol lowering drugs.

Process for the preparation of beta hydroxy-delta lactone using novel intermediates

Process for the preparation of &bgr; hydroxy-&dgr; lactone using novel intermediates

One pot process for the preparation of 1-&lsqb;2-dimethylamino-(4-methoxyphenyl)-ethyl&rsqb;cyclohexanol

A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial Microorganisms (NCIM), National Chemical Laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30&deg; C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

Microbial process for the production of D(-)-N-carbamoylphenylglycine

The present invention relates to a process for the preparation of D(-)N-carbamoylphenylglycine, by growing Pseudomonas sp deposited at National Collection of Industrial Microorganisms, Pune, India and at American Type Cultural Centre, Rockville, U.S.A and afforded accession No. ATCC 55940 in a conventional nutrient, medium, suspending the cells in alkaline buffer containing buffer, acidifying the broth to obtain the product.

Halophilic Pseudomonas strain having accession No.NCIM 5109 (ATCC 55940)

A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial microorganisms (NCIM), National Chemical laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30.degree. C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

Codeine is prepared by reacting morphine with trimethyl phenyl ammonium chloride in the presence of an alkali metal carbonate and a hydrocarbon solvent at a temperature of from 40.degree. to 120.degree. C. Codeine is recovered from the reaction mixture. Codeine is useful as an analgesic and antitussive drug.

Process for the preparation of codeine from morphine

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Maharashtra, India

Uttam Ramrao Kalkote