Dicerna Pharmaceuticals, Inc.

Novo Nordisk A/s

Novo Nordisk Healthcare Ag

Utsav Saxena

Henryk T Dudek

Bob Dale Brown

Natalie Wayne Pursell

Cheng Lai

Weimin Wang

Naim Nazef

Boyoung Kim

Rachel Storr

Marc Abrams

Birgitte Andersen

Wen Han

Anton Turanov

Nicole Alexis Spiegelman

Markus Robert Latta

Bob D Brown

Natalie Pursell

Oligonucleotides and compositions including the same are disclosed for inhibiting or reducing apolipoprotein C-III (APOC3) gene expression. Methods of making and using the oligonucleotides also are disclosed, particularly uses relating to treating diseases, disorders and/or conditions associated with APOC3 expression.

Compositions and methods for modulating APOC3 expression

Oligonucleotides and compositions including the same are disclosed for inhibiting or reducing patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene expression. Methods of making and using the oligonucleotides also are disclosed, particularly uses relating to treating diseases, disorders and/or conditions associated with PNPLA3 expression.

Compositions and methods for modulating PNPLA3 expression

This disclosure relates to oligonucleotides, compositions and methods useful for reducing ALDH2 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of ALDH2 expression may be double-stranded or single-stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of ALDH2 expression may also include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat alcoholism and related conditions.

Compositions and methods for inhibiting ALDH2 expression

This disclosure relates to oligonucleotides, compositions and methods useful for reducing LDHA expression, particularly in hepatocytes.

Methods and compositions for inhibiting expression of LDHA

Oligonucleotides are provided herein that inhibit NR1H3 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with NR1H3 expression.

Compositions and methods for inhibiting nuclear receptor subfamily 1 group H member 3 (NR1H3) expression

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Lexington, MA, United States of America

Utsav Saxena