Godecke Aktiengesellschaft

Goedecke Aktiengesellschaft

Warner-lambert Company

Ute Weiershausen

Gerhard Satzinger

Edgar Fritschi

Manfred F Herrmann

Hartmut Osswald

Wolfgang Dieter Herrmann

Karl-Otto Vollmer

Volker Ganser

Gunter Wolf

Manfred Hermann

The present invention provides substituted N-(2'-aminophenyl)-benzamide derivatives useful for combating neoplastic diseases. The present invention also provides a process for the preparation of these benzamide derivatives, as well as pharmaceutical compositions containing them and methods for using them.

N-(2'-aminophenyl)-benzamide derivatives process for the preparation

N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling refractory tumors in mammals are described.

N-phenylbenzamide derivatives

The use of benzothiazepine derivatives for the protection of lymphocytes in humans and higher mammals, especially in the treatment of acquired immune deficiency syndrome.

Use of benzothiazepine derivatives as lymphocyte protectors

N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.

The present invention provides combination of materials for strengthening the antithrombotic action of acetylsalicylic acid. It covers a composition which contains diltiazem or a pharmaceutically acceptable acid-addition salt thereof in combination with acetylsalicylic acid. It also forms the new compound diltiazem acetysalicylate. It also covers compositions containing the above and methods for using the compositions or compound.

Growing community of inventors

Gundelfingen, Germany

Ute Weiershausen