Pioneer Hi-Bred International, Inc.

E.i. Dupont De Nemours and Company

Crimson U.S. Assets LLC

Scios Inc.

Pioneer Hi-Bred Interantional, Inc.

Corteva Agriscience LLC

Ute Schellenberger

Genhai Zhu

Weiping Xie

Jun-Zhi Wei

Lu Liu

Barbara Rosen

Steven D Gruver

Jessica O'Rear

Xiaohong Zhong

Ingrid Udranszky

Jarred Kenneth Oral

Heather Kozy

Eric J Schepers

Nasser Yalpani

James J English

Brad Poland

Andre R Abad

Scott H Diehn

Jennifer Kara Barry

Randall W Nelson

Thomas Chad Wolfe

Jimei Wang

Zhenglin Hou

Lan Zhou

Phillip A Patten

Albert Laurence Lu

James Kevin Presnail

Omid Vafa

Ryan Michael Gerber

Daniel J Altier

Azalea S Ong

David Charles Cerf

Carol A Hendrick

Takashi Yamamoto

Xu Hu

Wim Van Schooten

Nathan D Trinklein

Shelley Force Aldred

Eric E Niederkofier

Yi Zheng

Kevin Hayes

Amy Lum

Katherine Harris

Jun-zhi Wei

Urban A Kiernan

Gusui Wu

Gary A Sandahl

Duy Pham

Michi Izumi Willcoxon

Jeffrey Sopa

Starlynn Clarke

Eric E Niederkofler

Angel Elizabeth Grace D'Oliviera

Wieping Xie

Young-Jun Park

Young Jun Park

Urban A Kieman

Jessica O'rear

Zun-Zhi Wei

Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

Insecticidal proteins and methods for their use

Insecticidal proteins from plants and methods for their use

Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity. Structure based methods for engineering insecticidal proteins of the disclosure to have modified physical properties are provided.

Structure based methods for modification of PIP-72 polypeptides and PIP-72 polypeptides derived therefrom

Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.

Method, composition and device for sampling natriuretic peptides in a biological fluid

Compositions and methods for controlling pests are provided. The methods involve transforming organisms with one or more nucleic acid sequence encoding insecticidal protein(s) and one or more silencing element(s). In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The molecular and breeding stacks find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

Insecticidal combinations of PIP-72 and methods of use

Growing community of inventors

Palo Alto, CA, United States of America

Ute Schellenberger