Abbvie Deutschland Gmbh and Co Kg

Abbvie Inc.

Abb Vie Deutschland Gmbh & Co. Kg

Abbott Gmbh & Co Kg

Ute Lander

Bernd Liepold

Kennan C Marsh

Jörg Breitenbach

Jörg Rosenberg

Christoph Schmidt

Ulrich Westedt

Gunther Berndl

Yi Gao

Nancy E Sever

Ping Tong

Harald Hach

Adivaraha Jayasankar

Marius Naris

Dietrich Granzow

Juergen Weis

Colleen Garrett

Donghua Zhu

Katharina Asmus

Samuel Kyeremateng

Michael Simon

Constanze Obermiller

Regina Reul

Thomas Mueller

Benedikt Steitz

Katrin Schneider

Michael Siimon

Jorg Rosenberg

Joerg Breitenbach

Kennan Marsh

The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Solid pharmaceutical compositions for treating HCV

A formulation comprising a melt-processed solid dispersion product comprising an active agent, a pharmaceutically acceptable thermoplastic polymer of N-vinyl lactams, and a pharmaceutically acceptable polyvinyl alcohol-polyalkylene glycol graft copolymer. A method for producing said formulation.

Solid retard formulations based on solid dispersions

Pharmaceutically acceptable solubilizing compositions comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono-and diester are disclosed. The solubilizing compositions are useful in the manufacture of pharmaceutical dosage forms comprising a melt-processed mixture of at least one active ingredient and at least one pharmaceutically acceptable polymer. The solubilizing compositions enhance the bioavailability of the active ingredient following oral intake.

Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same

A pharmaceutically acceptable solubilizing composition comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono- and diester is disclosed. The solubilizing composition is useful in the manufacture of a pharmaceutical dosage form which comprises a melt-processed mixture of at least one active ingredient, at least one pharmaceutically acceptable polymer. The active ingredient(s) may be inhibitors of HIV protease. The solubilizing composition enhances the bioavailability of the active ingredient after oral intake.

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Dannenfels, Germany

Ute Lander