Sartorius Stedim Biotech Gmbh

Sartorius Stedim Fmt Sas

Ute Husemann

Gerhard Greller

Oscar-Werner Reif

Thomas Dreher

Bernward Husemann

Oliver Scheibe

Thomas Loewe

Stefan Weisshaar

Thomas Regen

Ralf Lausch

Thomas Friese

Paschalis Nikoloudis

Simon Topp-Manske

Magali Barbaroux

Stefan Zeuch

Reiner Seitz

Rainer Salzmann

Guenter Pradel

Christian Zahnow

Matthias Hielscher

Lucie Delaunay

A film for manufacturing a pouch includes a contact layer including (A) a copolymer of ethylene and α-olefin having a density in the range of 0.870 g/cmto 0.910 g/cm, alone or in mixture with (B) a polyolefin having a density in the range of 0.910 g/cmto 0.940 g/cm, the contact layer including less than 0.10 wt %, preferably less than 0.07 wt %, of additives able to release a degradation compound further to gamma irradiation in the range of 25 kGy-50 kGy that can slow down or delay cellular growth. The process for manufacturing such a film, as well as the single-use pouch manufactured from that film are also described.

Film comprising a contact layer for the wall of a single-use pouch

A probe holder (), for positioning at least one probe () such that the probe () at least partially engages in a system () for biotechnological uses, comprises a holder base () for positioning the probe holder () on the system () for biotechnological uses and at least one probe positioning means (), which is designed to position the at least one probe () such that the probe () extends in a probe extension direction (S; S, S, S, S). The probe positioning means () is positioned on the holder base () such that the position of the probe () is variably adjustable in a probe extension direction (S; S, S, S, S).

Probe holder and method for positioning a probe

A receptacle has a wall defining a receptacle interior and a shaft housing for guiding a shaft through the wall into the receptacle interior. The shaft housing defines an annular cap with spaced apart inner and outer walls connected by an inner end face facing the receptacle interior. A shaft guide part has an end facing the receptacle interior and an outer surface that defines a gap relative to the inner wall of the shaft housing. The shaft guide part has an annular wall spaced apart from and parallel to its outer surface. The annular wall extends over the free end of the inner wall of the shaft housing and is sealed to the inner and outer walls of the shaft housing by at least one seal each. The shaft guide part is mounted in the shaft housing by a radial ball bearing and by an axial ball bearing.

Receptacle comprising a shaft housing

A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.

Stirrer installation aid and method for installing a stirrer element in a bioreactor

The invention relates to a device for culturing cells in a bioreactor, the waste-air line of which leading out of the reactor interior comprises a waste-air filter having a sterile-filtration microfilter membrane, wherein at least one prefilter having a hydrophobic filter material is placed upstream of the waste-air filter toward the reactor interior.

Combined filter

A device and a method for adjusting stirring blades on a stirring blade receptacle of a stirrer, wherein the stirring blades can be fixed with a stirring blade axis in receiving bores, which are arranged transversely to an axis of rotation and are a part of the stirring blade receptacle, at intended predetermined angle of attack relative to a virtual plane that is arranged transversely to the axis of rotation of the stirrer. An associated device body is provided with a receiving element for receiving the stirring blade receptacle with unfixed stirring blades. A stop is arranged on the device body for each lower face, which faces the receiving element and is a part of the stirring blades, outside the respective stirring blade axis. Each respective stirring blade is then brought into abutment against its associated stop, to place it into the predetermined angle of attack.

Device and method for adjusting stirring blades

Aeration device for bioreactors with a first aeration element with gas outlet openings of a first size and with at least one second aeration element with gas outlet openings of a second size, the aeration elements being formed by a common housing with separate aeration channels.

Aeration device for bioreactors

Growing community of inventors

Goettingen, Germany

Ute Husemann