Imtm Gmbh

Keyneurotek Pharmaceuticals Ag

Ute Bank

Siegfried Ansorge

Frank Striggow

Klaus Neubert

Michael Täger

Jürgen Faust

Michael Taeger

Bianca Senns

Irene Reichstein

Karsten Nordhoff

Petra Fuchs

Compounds of the general formulae (1) and (2)A-B-D-B'-A&#x2032;&#x2003;&#x2003;(1)andA-B-D-E&#x2003;&#x2003;(2)in which 

Dual-use peptidase inhibitors as prodrugs for a therapy of inflammatory and other diseases

The present invention relates to substances capable of specifically inhibiting Ala-p-nitroanilide-cleaving peptidases and Gly-Pro-p-nitroanilide-cleaving peptidases as well, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).

Dual alanyl aminopeptidase and dipeptidyl peptidase iv inhibitors for functionally influencing different cells and for treating immunological inflammatory, neuronal and other diseases

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Stassfurt, Germany

Ute Bank