Baylor University

Oxigene, Inc.

Usha Ghatak, Legal Representative

Kevin G Pinney

David J Chaplin

Zhi Chen

Klaus Edvardsen

Joseph Anthony Prezioso

James Michael Dorsey

Vani P Mocharla

Charles M Garner

Mallinath Hadimani

Raymond Kessler

A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

Tubulin binding ligands and corresponding prodrug constructs

Growing community of inventors

Salt Lake City, UT, United States of America

Usha Ghatak, Legal Representative