Pfizer Corporation

Usa Reilly

Matthew Frank Brown

Justin Ian Montgomery

Ye Che

Michael Joseph Melnick

Anthony Marfat

Michael Joesph Melnick

Mark Stephen Plummer

Loren Michael Price

Jinshan Michael Chen

Takushi Kaneko

Mark Edward Flanagan

Richard Andrew Ewin

Louis Stanley Chupak

Timothy Allan Johnson

Thomas V Magee

Tamim F Braish

Mark Carl Noe

Daniel Paul Uccello

Joseph Alan Abramite

Joseph A Abramite

Mathew Frank Brown

The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH), —P(O)(OH)(OM), —P(O)(OM)and —P(O)(O)M; Mat each occurrence is a pharmaceutically acceptable monovalent cation; and Mis a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Fluoro-pyridinone phosphates and boronates useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.

N-link hydroxamic acid derivatives useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, Rand Rare as described hereinabove, and their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.

C-linked hydroxamic acid derivatives useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents

Fluoro-pyridinone derivatives useful as antibacterial agents

Isoxazole derivatives useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives of formula I, 

N-linked hydroxamic acid derivatives useful as antibacterial agents

Macrolide compounds per se, as shown below and defined herein, and their use, e.g., as antibacterial and antiprotozoal agents in animals, including humans: Also disclosed are methods of preparing the compounds, intermediates, and pharmaceutical compositions thereof, and methods of treating or preventing disease by administering the compounds to subjects in need. This abstract is only an excerpt and is not limiting of the invention.

Macrolides

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Usa Reilly