Roche Diagnostics Operations, Inc.

F. Hoffmann-la Roche Ag

Ursula Kunert

Johann Karl

Herbert Andres

Magdalena Swiatek-de Lange

David Morgenstern

Marion Niessner

Nina Meissler

Marie-Luise Hagmann

Gabriele Pestlin

Stefan Weiser

Florian Grupp

An in vitro method is disclosed for detecting an antibody to p53 (anti-p53 antibody) in a sample, the method comprising: incubating a sample to be analyzed with a p53 capture antigen and a p53 detection antigen, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody and the p53 detection antigen is formed, separating the complex formed from unbound detection antigen and measuring the complex obtained via the detection antigen comprised therein, thereby detecting the anti-p53 antibody comprised in the sample.

Detection of anti-p53 antibodies

Described is a method aiding in the assessment of rheumatoid arthritis ('RA'). The method is used in assessing RA in vitro. It is practiced by analyzing biochemical markers, including measuring the concentration of anti-CCP and anti-PIK 3CD and correlating the concentrations determined to the absence or presence of RA. Also disclosed is the use of a marker panel including anti-CCP and anti-PIK3CD in the diagnosis of RA and it teaches a kit for performing the method. Also described is the use of a marker panel comprising anti-CCP and anti-PIK3CD to differentiate RA from other autoimmune diseases, preferably osteoarthritis (OA).

Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-PIK3CD

The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein ASC (apoptosis-associated speck-like protein containing a caspase-associated recruitment domain) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of colorectal cancer.

ASC as a marker for colorectal cancer

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Munich, Germany

Ursula Kunert