Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Ursula Klause

Rupert Herrmann

Helmut Lenz

Dieter Heindl

Herbert Von Der Eltz

Hans-Peter Josel

Christoph Seidel

Johann Karl

Elke Faatz

Erasmus Huber

Barbara Upmeier

Peter Sluka

Christine Markert-Hahn

Beatus Ofenloch-Hahnle

Veit Peter Grunert

Andreas Finke

Wolfgang Jona

Pavel Kubalec

Matthias Rothfuss

Paul Delmar

Federic Donie

Sanne Lysbet De Haas

Dorothee Foernzler

Stefan Scherer

Methods and system for determination of an anti-&#x3c;therapeutic monoclonal antibody&#x3e; antibody (anti-&#x3c;TmAB&#x3e;AB) in vitro in a sample from a patient treated with a therapeutic monoclonal antibody (TmAB). Also, methods and systems for the determination of antigen specific antibodies of a particular immunoglobulin class and for the identification of a patient who is at risk of developing an adverse drug reaction (ADR) during treatment with a TmAB.

Assay for measurement of antibodies binding to a therapeutic monoclonal antibody

The invention concerns a method for determining antigen-specific antibodies of a particular immunoglobulin class in a sample by means of an immunoassay in an array format in which various binding partners Bare bound on different discrete areas on a support where Bin each case contain the various antigens that are able to specifically bind to the antibodies to be detected, by incubating the support with the sample and a binding partner Bwhich carries a label and subsequently detecting the label on the respective discrete areas wherein Bspecifically binds antibodies of a certain immunoglobulin class that have been bound in an antigen-specific manner.

Immune complex-specific antibodies for increased sensitivity in immunoassay array tests

The present invention concerns a method for producing microparticles loaded with proteins which is characterized in that the microparticles are loaded in suspension under strongly alkaline conditions. The invention also concerns microparticles which can be produced using this method and their use in a binding test e.g. in an immunoassay.

Method for producing microparticles loaded with proteins

The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converted into the leaving group. The invention also relates to compounds additionally comprising a coupling group to the use of such compounds for labeling of biomolecules and more generally to the use of such compounds in chemiluminescence detection procedures.

Compounds for chemiluminescense procedures

The invention concerns the use of peptides which are comprised essentially of D-amino acids to eliminate interference in diagnostic methods, a method for eliminating interference in diagnostic methods by peptides which are comprised essentially of D-amino acids as well as a reagent that eliminates interference containing at least one peptide which is comprised essentially of D-amino acids.

Elimination of interference in diagnostic methods by peptides comprising

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Peissenberg, Germany

Ursula Klause