Hoffmann-la Roche Inc.

Genentech, Inc.

F. Hoffmann-la Roche Ag

Ursula Hoffmann

Michelangelo Scalone

Francis Gosselin

Kurt Puentener

Reinhard Reents

Helmut Werner Stahr

Pirmin Hidber

Michael Jansen

Goesta Rimmler

Dennis A Smith

Srinivasan Babu

Stephan Bachmann

Stefan Hildbrand

Bruno Lohri

Fabienne Hoffmann-Emery

Qingping Tian

Shaoning Wang

Tim Sattelkau

Alec Fettes

Roland Meier

Serena Maria Fantasia

Herbert Yajima

Zhigang Cheng

Pascal Dott

Georg Wuitschik

Gerard Moine

Pankaj Rege

Theresa Humphries

Wolfgang Goehring

Lukas Chytil

Timothy Smyth

Declan Costello

Rene Lebl

Gerard John Hamett

Thomas McCarthy

Christian Oliver Kappe

Fabian Feyen

Gerard John Harnett

Thomas Mccarthy

Helmut Stahr

Paolo Tosatti

Jason Douglas Williams

Methods for preparing the Bruton's Tyrosine Kinase ('BTK') inhibitor compound 2-{3'-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.

Process for preparing BTK inhibitors

The present invention relates to a process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.

Process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one compounds

Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure:  and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.

Process for making thienopyrimidine compounds

The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is a useful pharmaceutical active compound.

Process

A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

Preparation for a cyclohexanecarboxylic acid derivative and intermediates

A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

Process for the preparation of acid halides

The present invention relates to a process for the preparation of 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of pharmaceutical active compounds.

Process for the preparation of CETP(1)

A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

Process for cyclohexanecarboxylic acid derivatives

Process for the production of acid chlorides

A novel process for the preparation of compounds of formula I and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I and the corresponding salts, e.g. the sodium salts, are pharmaceutically active substances. Processes for the creation of intermediates are also disclosed.

Process for the preparation of the insulin sensitizer

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Muttenz, Switzerland

Ursula Hoffmann