Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

Ursula-Henrike Wienhues

Christoph Seidel

Michael Wiedmann

Urban Schmitt

Barbara Upmeier

Manfred Motz

Erwin Soutschek

Elke Faatz

Eva H&ouml;ss

Eva Höss

Hans-Peter Josel

Beatus Ofenloch-Hahnle

Hubert Bayer

Hans Georg Ihlenfeldt

Beatus Ofenloch-H&auml;hnle

Beatus Ofenloch-Hähnle

Cornelia Kruse-M&uuml;ller

Cornelia Kruse-Müller

The invention concerns a method for the immunological determination of a specific antibody in a sample liquid in which the sample liquid is incubated in the presence of a solid phase with two antigens directed against the antibody to be determined of which the first antigen carries at least one marker group and the second antigen is (a) bound to the solid phase or (b) is present in a form capable of binding to the solid phase and the antibody to be determined is detected by determining the marker group in the solid phase or/and in the liquid phase characterized in that at least one of the two antigens contains several epitope regions which react with the antibody to be determined.

Determination of a specific immunoglobulin using multiple antigens

The invention concerns a process for the production of metal chelate-labelled peptide antigens, peptides obtainable by this process and their use in an immunological method of detection.

Metal chelate-labelled peptides

The present invention concerns a polypeptide which is composed of the amino acids 1207&#xb1;10 to 1488&#xb1;10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

Method for determining early HCV seroconversion

Metal chelate-labelled peptide which has a maximum length of 50 amino acids and is coupled to at least one luminescent metal chelate at the amino terminus or/and at amino side groups, wherein the at least one luminescent metal chelate is present on the peptide at a predetermined position on the peptide.

The present invention concerns a polypeptide which is composed of the amino acids 1207&plusmn;10 to 1488&plusmn;10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

Recombinant antigen from the NS3 region of the hepatitis C virus

The present invention concerns a polypeptide which is composed of the amino acids 1207.+-.10 to 1488.+-.10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

Metal complexes with a charged linker

Hapten-labelled peptides

New HCV peptide antigens are described. These peptide antigens are suitable for the determination of HCV antibodies as immunogens for the preparation of antibodies to HCV and as immunogens for the preparation of vaccines to HCV.

Growing community of inventors

Krailling, Germany

Ursula-Henrike Wienhues