Ciba-geigy Corporation

Novartis Ag

Sandoz Ag

Novartis Consumer Health S.a.

Norvartis Corporation

Urs Siegrist

Peter Baumeister

Martin Studer

Henry Szczepanski

Thomas Pitterna

Jozef Drabek

Willy Meyer

Rolf Schurter

Hermann Rempfler

Paul Adriaan Van Der Schaaf

Frank Bienewald

Manfred Muller

Hans-Peter Jalett

Robert Hassig

Vadiraj Subbanna Ekkundi

Vilas N Mumbaikar

Niranjan Paingankar

Jean Indermuhle

Jean Brunisholz

Stefan Burkhardt

Disclosed is a process for the preparation of a compound of formula wherein wherein R, Rand n are as defined above, in the presence of a nickel or cobalt catalyst.

Process for the preparation of phenethylamine derivatives

The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon multiple bonds, nitrile groups, imino groups or carbonyl groups. The preparation is carried out by catalytic hydrogenation of the corresponding aromatic nitro compounds in the presence of a phosphorus-modified noble metal catalyst. The invention relates also to the use of modified noble metal catalysts for the hydrogenation of aromatic nitro compounds containing carbon multiple bonds and/or substituted by nitrile, imino or carbonyl groups.

Process for the preparation of substituted aromatic amino compounds

The present invention relates to a hydrogenation process for the production of aromatic halogen-amino compounds by means of catalytic hydrogenation on noble metal catalysts of corresponding aromatic halonitro compounds, characterised in that a rhodium, ruthenium, iridium, platinum or palladium catalyst which is modified with an inorganic or organic phosphorus compound with a degree of oxidation of less than V, is used, in the presence of a vanadium compound.

Process for the production of aromatic halogen-amino compounds

Process for the preparation of aromatic O-sulfocarboxylic acids and

Process for the preparation of unsaturated amino compounds

A process for the preparation of an aqueous medium of nicotinaldehyde by the catalytic reduction of 3-cyanopyridine under hydrogen in the presence of Raney-nickel.

Process for the preparation of aqueous nicotinaldehyde

A process for the preparation of 6-alkyl-4-(pyridin-3-yl-methyleneamino)-4,5-dihydro-1,2,4-triazin-3(2H)-on e by the reaction of 4-amino-6-alkyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine with 3-cyanopyridine wherein the reaction is carried out under catalytic hydrogenation conditions in the presence of a Raney-nickel catalyst in an aqueous alcoholic medium, at a temperature between 0.degree. and 70.degree. C., at a pH of between 2 and 7, and in the presence of and a C.sub.1 -C.sub.6 -carboxylic acid or a C.sub.1 -C.sub.6 -carboxylic acid alkali metal salt or both, whereby the hydrogen pressure is between 0.1 and 10 bar.

Process for the preparation of

(3-Fluoropyridin-2-yloxy)phenoxypropionic acids of formula I ##STR1## wherein X is hydrogen, fluoro, chloro, bromo or trifluoromethyl and Y is hydrogen, sodium or potassium, are prepared by reacting a compound of formula II ##STR2## wherein X and Y are as defined for formula I, in an anhydrous mixture of hydrogen fluoride, dimethylsulfoxide and a diazotising agent under normal pressure, and converting the diazonium fluoride so produced by thermal decomposition into the (3-fluoropyridin-2-yloxy)phenoxypropionic acid of formula I.

Process for the preparation of (3-fluoropyridin-2-yloxy)phenoxypropionic

There is disclosed a multi-step process for the preparation of benzenesulfonamides of general formula ##STR1## wherein R is 3,3-difluorobutyl or 3,3-difluorobuten-1-yl. The benzenesulfonamides obtainable by the process of the invention are intermediates for the synthesis of herbicidally active sulfonyl ureas.

Process for the preparation of benezenesulfonamides

Novel substituted N-benzoyl-N'-2,5-dihalo-4-perfluoroalkoxyphenylureas of formula I ##STR1## in which R.sub.1 is hydrogen, fluorine, chlorine or bromine; R.sub.2 is fluorine or chlorine; each of R.sub.3 and R.sub.4 is fluorine, chlorine or bromine; and n is 2, 3, 4, 5, 6, 7 or 8, processes and intermediates for their prepraration, their use in pest control, and pesticidal compositions that contain at least one compound of formula I as active ingredient, are disclosed. The preferred field of application is the control of pests in and on animals and plants.

N-benzoyl-N'-2,5-dihalo-4-perfluoroalkoxyphenylureas, pesticidal

In accordance with a novel process, 2,3-difluoropyridines of formula I ##STR1## wherein X is halogen or trifluoromethyl, are prepared by diazotising a 3-amino-2-halopyridine of formula II ##STR2## wherein X is as defined for formula I and Y is bromine, chlorine or fluorine, in the presence of hydrogen fluroide, to give a 3-fluoro-2-halopyridine of formula III ##STR3## wherein X and Y are as defined for formula II, and treating resultant 3-fluoro-2-halopyridines of formula III, wherein Y is bromine or chlorine, with a fluorinating agent. The 2,3-difluoropyridines prepared by the novel process are valuable intermediates for the preparation of 2-[4-(3-fluoropyridin-2-yloxy)-phenoxy]propionic acid derivatives which are known as herbicides.

Process for the preparation of fluorinated pyridine derivatives

The present invention relates to a novel process for the preparation of an .alpha.,.alpha.-difluoroalkyl phenyl ether of formula I ##STR1## wherein R.sup.1 is hydrogen, halogen, amino, nitro, --SO.sub.2 --R.sup.4, --S--R.sup.5, --SO--R.sup.6 or --S--S--R.sup.7,

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Eiken, Switzerland

Urs Siegrist