Ciba-Geigy Corporation

Ciba Specialty Chemicals Corporation

Ciba-Geiby Corporation

Urs Burckhardt

Dieter Reinehr

Manfred Kuhne

Jean J Gallay

Richard Josef Troxler

Manfred Boger

Rudolf Zink

Werner Topfl

Ernst Beriger

Haukur Kristinsson

Alfred Meyer

Walter Traber

Werner H&ouml;lzl

Gunter Mattern

Bernardo De Sousa

Hanspeter Sauter

Hans-Rudolf Waespe

Armando Di Teodoro

Lucius Werthemann

Uwe Gronde

Raafat Soliman

A process for the preparation of halohydroxydiphenyl compounds useful for protecting organic materials and articles from microorganisms, of the formula

Process for the preparation of halogenated hydroxydiphenyl compounds

The N-acylsulfamoylphenylureas of formula I below are suitable as counter-agents (antidotes or safeners) for protecting cultivated plants from the phytotoxic action of herbicides. Suitable crops are preferably cereals, soybeans, sorghum, maize and rice, and suitable herbicides are sulfonylureas, chloroacetanilides and aryloxyphenoxypropionic acid derivatives. The N-acylsulfamoylphenylureas have the formula I ##STR1## wherein A is a radical selected from the group ##STR2## R.sub.1 is C.sub.1 -C.sub.4 -alkoxy or each of R.sub.1 and R.sub.2, independently of the other, is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, ##STR3## or C.sub.1 -C.sub.4 alkyl substituted by C.sub.1 -C.sub.4 alkoxy or by ##STR4## or R.sub.1 and R.sub.2 together form a C.sub.4 -C.sub.6 alkylene bridge, or a C.sub.4 -C.sub.6 alkylene bridge interrupted by oxygen, sulfur, SO, SO.sub.2, NH or by --N(C.sub.1 -C.sub.4 alkyl)-, R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.a to R.sub.h, R.sub.x and R.sub.y are as defined in the disclosure.

Sulfamoylphenylureas

The invention relates to milbemycin derivatives of formula I ##STR1## wherein R.sub.1 is an aliphatic or aromatic radical or is a pyridyl ring or a heterocyclic oxygen-containing 5- or 6-membered ring, all of which may also be bound through oxygen, and R.sub.2 is methyl, ethyl or isopropyl. These compounds are suitable for controlling arthropode species such as injurious insects or endo- or ectoparasites of animals and are employed in the form of compositions. The compounds can also be used as intermediates for obtaining further milbemycin derivatives.

Milbemycin derivatives and the use thereof in pest control

Novel phenylcarbamoylbarbituric acid derivatives of the general formula I ##STR1## and tautomeric forms and salts thereof in which R.sub.1 and R.sub.2 independently of one another are C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.3 -alkoxy, C.sub.3 -C.sub.6 -cycloalkyl, allyl or phenyl; R.sub.3 is substituted or unsubstituted pyridyl as herein defined; and X is oxygen or sulfur; they possess anthelmintic activity. The active substances can be employed in conjunction with suitable carriers and further adjuncts for controlling zooparasitic helminths.

5-(pyridyloxy- or pyridylthio-phenyl)carbamoyl barbituric acid

The use in pest control of 2-(1-indolinylmethyl)-imidazolines of the formula I ##STR1## or salts thereof, wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.12 -alkyl,

Method and compositions for controlling insects, and members of the

The invention relates to a composition for protecting keratinous material, in particular woollen textiles, from attack by pests that feed on keratin, in particular moth and beetle larvae, which composition contains, as active ingredient combination, a specifically substituted 5-(pyridyloxyphenylcarbamoyl)barbituric acid or a salt thereof and a synthetic pyrethroid, as well as to a process comprising the use of this active ingredient combination for providing said material with a protective finish against attack by pests that feed on keratin.

Mothproofing and beetleproofing composition: 5-(pyridyloxy- or

The compound of formula I ##STR1## wherein R.sub.2 is methyl, ethyl, isopropyl or sec-butyl, can be prepared by selective chlorination of an appropriate milbemycin derivative either with hypochlorous acid (HOCl) or sulfuryl chloride (SO.sub.2 Cl.sub.2) in the temperature range from -10.degree. to +60.degree. C. It is employed as pesticide for controlling Arthropode species such as injurious insects or ecto- or endoparasites of animals, and is applied in the form of compositions. This compound is also used as intermediate for obtaining further milbemycin derivatives.

Lactone derivative, process for the preparation thereof, and use thereof

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 independently of one another are each a chlorine atom or the methyl group, Y is the group ##STR2## or --CH.dbd.N--R.sub.5, in which R.sub.3 is methyl or ethyl, R.sub.4 is alkyl having 1 to 4 carbon atoms, alkoxy having 1 or 2 carbon atoms, alkylthio having 1 to 4 carbon atoms, or phenyl, X is an oxygen atom or a sulfur atom, and R.sub.5 is an unsubstituted or substituted pyridinyl group which is linked by way of one of its carbon atoms, to the main part of the molecule, and which has substituents selected from the group comprising halogen and alkyl having 1 to 4 carbon atoms, including the acid addition salts thereof, processes for producing the novel compounds by reaction of 2-(anilinomethyl)-2-imidazoline derivatives either with (thio)phosphoric acid dialkyl ester halides or alkyl(thio) phosphonic acid alkyl ester halides, or with N-pyridinylformiminoalkoxy derivatives. The resulting compounds and compositions containing them are effective against members of the order Acarina, and against animal and plant lice, as well as against members of the Calliphoridae family.

Substituted 2-(anilinomethyl)-2-imidazoline derivatives, compositions

A process for the production of desoxy-.alpha.-acids from the corresponding .beta.-acids is disclosed which process comprises converting a .beta.-acid into a mixture of its monoacylation products and subsequently reacting the monoacylation product at 160.degree. to 250.degree. C., in the presence of a lower alkanoic acid with an anhydride of such an alkanoic acid, with the splitting-off of isoprene, to obtain the triacyl derivative of the corresponding desoxy-.alpha.-acid, and hydrolysing said triacyl derivative to obtain the desoxy-.alpha.-acid. Desoxy-.alpha.-acids are valuable intermediates for producing bitter principles, which are used in the foodstuffs and drinks industry.

Process for producing desoxy-.alpha.-acids

Preparation of deoxy-.alpha.-acids (deoxyhumulons) by prenylation of the corresponding acylphloroglucinols under alkaline conditions, whereby prenylation is performed in a mixture of water and an organic solvent immiscible with water, in the presence of a phase-transfer catalyst.

Process for the production of deoxy-alpha-acids

The present invention relates to new compositions, containing as active ingredient 4-nitro-5-carbamoyl-imidazole derivatives, which compositions are for the treatment and prevention of coccidiosis in poultry. The 4-nitro-5-carbamoyl-imidazole derivatives correspond to the following general formula I ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, or an alkyl radical having 1 to 4 carbon atoms.

Growing community of inventors

Basel, Switzerland

Urs Burckhardt