Beta-o2 Technologies Ltd.

Glusense Ltd.

Beta 02 Technologies Ltd.

Bonus Therapeutics Ltd.

Uriel Barkai

Avi Rotem

Tova Neufeld

Yehezkel Bremer

Zohar Gendler

Yoram Rozy

Yaki Stern

Samer Srouji

Pnina Vardi

Shai Meretzki

Konstantin Bloch

Meir Reingewirtz

Chanan Schneider

Yoav Evron

Zohar Biron-Sorek

Baruch Zimerman

Dimitry Azarov

Proteins () having glucose-binding sites () that bind to glucose () are described.

FRET-based glucose-detection molecules

A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.

Multiple-layer immune barrier for donor cells

An implantable medical system that comprises a gas unit for supplying gas that is essentially oxygen and at least one functional cells unit configured to receive oxygen from the gas unit so as to maintain the cells in a viable condition. The cells unit is flexible. Several embodiments are disclosed.

Implantable medical devices

Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space () of a kidney () of a subject and is shaped to define a planar configuration. Other applications are also described.

Optimization of alginate encapsulation of islets for transplantation

Apparatus is provided, including a housing (), configured for insertion into a body of a patient; a photosynthetic oxygen supply () configured to supply oxygen; and functional cells (), coupled to the housing (). The functional cells () are adapted to receive the oxygen and to secrete at least one factor that induces vascularization in a vicinity of the housing () when the housing () is in the body of the patient. Other embodiments are also described.

Oxygen supply for cell transplant and vascularization

Apparatus is provided which includes a housing, configured for insertion into a body of a subject. The apparatus includes functional cells coupled to the housing and a source of oxygen configured to supply oxygen to the functional cells. The apparatus further includes an oxygen delivery interface configured to receive oxygen from the source of oxygen, and to facilitate passage of the oxygen to the functional cells, while the housing is disposed within the body of the subject. Other embodiments are also described.

Apparatus for transportation of oxygen to implanted cells

Growing community of inventors

MP Hof-Carmel, Israel

Uriel Barkai