Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Ben-Gurion University of the Negev Research and Development Authority

Other

Uri Wormser

Amnon Sintov

Synthetic peptides containing chemical modifications having anti-tumor properties are provided. Further provided are pharmaceutical compositions including the peptides and use thereof for treating proliferative and neoplastic diseases such as cancer.

Peptides for the treatment of malignant proliferative diseases

Isolated polypeptides comprising the amino acid sequence of residues 378-413 of&#x3b1;-1-antitrypsyn (serpin A1c),active fragments thereof, and pharmaceutical compositions comprising same are described. The compositions are useful for treating burns, inflammatory, autoimmune and degenerative diseases.

Pharmaceutical compositions containing polypeptides derived from &#x3b1;-1 antitrypsin and methods of use thereof

The invention relates to isolated peptides derived fromJaponica Group, pharmaceutical compositions comprising same, and uses thereof for treating, preventing, ameliorating, and/or delaying the onset of inflammatory and/or neuroinflammatory and/or autoimmune diseases or conditions and in particular multiple sclerosis. The invention further relates to extracts fromJaponica Group and use thereof as a dietary supplement or in a pharmaceutical composition for treating, preventing, ameliorating, and/or delaying the onset of inflammatory, and/or inflammatory, neuroinflammatory and/or autoimmune diseases or conditions. The peptides and the extract of the invention may be used for treating, ameliorating, and/or delaying the onset or preventing multiple sclerosis.

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Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of histone H2A and fibrinopeptide A, and preferred derivatives of these peptides are disclosed. Pharmaceutical compositions and methods of using these peptides are also disclosed. The extracts, peptides and pharmaceutical compositions according to the invention are useful for the prevention and treatment of inflammatory conditions and exposure to noxious stimuli.

Protective factors against inflammation, burns and noxious stimuli

Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury induced by noxious stimuli when administered to animals. Pharmaceutical compositions and methods of using these peptides are also disclosed. The pharmaceutical compositions according to the invention are useful for treating and protecting against inflammatory diseases, autoimmune diseases, for treating and protecting against tissue damage, for inhibiting metalloproteinase activity, and for treating and protecting against diseases associated with the breakdown of extracellular matrix or connective tissues.

Histone H2A peptide derivatives and uses thereof

Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of histone H2A and fibrinopeptide A, and preferred derivatives of these peptides are disclosed. The extracts, peptides and pharmaceutical compositions according to the invention are useful for the preparation and treatment of inflammatory conditions and exposure to noxious stimuli.

The invention provides a composition of matter comprising molecular iodine and tetraglycol.

Composition containing molecular iodine

The invention provides a transdermal delivery system for treating diabetes and other pathologic systemic conditions, comprising an active ingredient selected from the group consisting of peptides and proteins having an S&mdash;S bond and mixtures thereof and a pharmaceutically acceptable oxidizing agent selected from the group consisting of iodine, povidine-iodine and sources thereof, said system being essentially free of reducing agents and said oxidizing agent enabling and facilitating the penetration of said active ingredient through the skin layers and into the blood stream.

Transdermal delivery system

A transdermal delivery system comprising an active ingredient selected from the group consisting of peptides, proteins and mixtures thereof and a pharmaceutically acceptable oxidizing agent. The transdermal delivery system is an easy-to-use topical system that facilitates the penetration of an active ingredient, such as insulin, through the skin layers and into the blood stream. Additionally, the invention includes a method for treating diabetes and other pathologic systemic conditions comprising administering an active ingredient selected from the group consisting of peptides, proteins and mixtures thereof and a pharmaceutically acceptable oxidizing agent.

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Jerusalem, Israel

Uri Wormser