Urifer Ltd.

Bar-llan University

Uri Nir

Sally Shpungin

Moshe Cohen

Etai Yaffe

Yoav Paas

Ilya Pittel

Barak Ben-David

Erez Pery

Adar Makovsky

The present disclosure is directed to a compound of formula (I) (E266) and its acceptable pharmaceutical salts, to pharmaceutical compositions comprising the compound and its use in the manufacture of medicaments for treating diseases.

2-(4-{1-[6-(4-isopropyl-phenyl)-imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-piperidin-4-ylmethyl}-piperazin-1-yl)-ethanol and use thereof

An isolated pore-forming polypeptide is disclosed which comprises a naturally-occurring plugging module and a naturally-occurring pore domain, wherein at least one amino acid of the pore-forming polypeptide is mutated to generate a protease cleavage site, serving to at least partially remove the plugging module from the pore domain. The pore forming polypeptides may be inserted into an encapsulating particle and positioned such that it is capable of forming a pore through the lipid layer of the particle in a presence of the protease.

Protease-activatable pore-forming polypeptides

Heterocyclic compounds of formula (I), (II), (III) or a pharmaceutically acceptable salt thereof: wherein R, Rand Rare each independently selected from hydrogen, halogen, Calkyl, Calkenyl, N&#x2014;(Calkyl), and N&#x2014;(Calkenyl), the Calkyl and Calkenyl being straight or branched; and Yand Yare selected from N and CH where one of Yand Yis N and the other is CH, are provided. Also provided are the synthesis of and pharmaceutical compositions including these compounds. These compounds and pharmaceutical compositions thereof can be used for the treatment of disorders, and in particular, cancer.

6-phenyl-2-[((piperidin-4-ylmethyl)-piperazin-1YL) or piperazin 1-ylmethyl)-piperidin-1-yl)]-imidazo[2,1-B][1,3,4]thiadiazole derivatives and their use

Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R)are as defined, and a physiological acceptable carrier. Also provided is a method for treating cancer including administering to an individual in need of such treatment an effective amount of the presently described pharmaceutical composition.

Pharmaceutical compositions and methods for the treatment of cancer

Methods and compositions for the diagnosis, prevention, and treatment of cancer are provided. More particularly, the present invention provides methods and compositions for the diagnosis, prevention, and treatment of cancer through detection and modulation of the expression of TMF/ARA160 and Fer.

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Moshav Gimzo, Israel

Uri Nir