Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Amsilk Gmbh

Uri Gat

Thomas Scheibel

Daniel Huemmerich

Shmulik Ittah

Noaa Barak

The present application relates to isolated amino acid sequence comprising multiple repeats of a semi-synthetic spider silk protein domain, or any functional homolog, variant, derivative, fragment or mutant thereof. The amino acid sequence of the invention further comprises an N-terminal region and a C-terminal region. The invention further provides a nucleic acid encoding the amino acid sequence of the invention, an expression vector comprising said nucleic acid, a host cell transformed with said expression vector, a recombinant spider silk protein thus produced and a fiber composed of the recombinant spider silk protein. The invention further encompasses a composition comprising as an active ingredient said amino acid sequence or any said recombinant protein or fiber comprising the same. Lastly, the invention relates to an article comprising at least one fiber composed of said recombinant spider silk protein.

Synthetic dragline spider silk-like proteins

The present invention is directed to a method of producing spider dragline and/or flagelliform proteins. The invention is further directed to a method of producing spider threads and to a dragline/flagelliform protein or dragline/flagelliform protein thread produced by these methods. The invention further provides the use of these proteins/threads in the field of biotechnology and/or medicine, in particular in the manufacture of wound closure or coverage systems, suture materials and in the manufacture of replacement materials, preferably artificial cartilage or tendon materials.

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Jerusalem, Israel

Uri Gat