Technion Research & Development Foundation Ltd

Uri Dinnar

Yael Nemirovsky

Arkadiy Morgenshtein

Noah Lotan

Meir Orenstein

Rafael Beyar

Samuel Sideman

Sarit Sivan

Menachem Halmann

David Elata

An ion concentration sensor produces a signal reflective of the ion concentration within a solution. The ion concentration sensor is based on an ion sensitive transistor having a solution input, a reference input, a diffusion input, and a diffusion output. The ion sensitive transistor is connected as a pass transistor, such that the diffusion output provides an electrical signal indicating an ion concentration in a solution contacting the solution input.

Ion concentration transistor and dual-mode sensors

Intravascular apparatus and method for locally treating a patient's blood vessel, are provided. The apparatus includes an implanted carrier ( ) for insertion into the vessel; and a biologically active agent ( ) immobilized to the carrier ( ), said biologically active agent ( ) reacting with a first substance to produce a second substance. The second substance is preferably a therapeutic agent, such as nitric oxide, for locally treating the vessel. The biologically active agent ( ) is preferably an enzyme such as nitrogen oxide synthase, and the first substance is preferably arginine introduced to the patient's body as part of a diet. According to another embodiment, the biologically active agent ( ) is a catalytic antibody and the first substance is a prodrug. Alternatively, the biologically active agent ( ) is a ribozyme. The method includes introducing into a patient's vessel an implantable carrier including a biologically active agent immobilized thereto, and reacting the biologically active agent with a first substance to locally produce a second substance.

Intravascular apparatus method

A method of displaying cardiac function which forms by helical or segmental analysis a three-dimensional cage model which can be shaded and color coded to indicate local and regional dysfunction by thickening or motion and stresses. On this model is superimposed the coronary artery tree including stenosed segments as obtained from the same patient by angiograms and the resulting three-dimensional coronary and mechanical model can be subjected to animation and analysis for diagnostic purposes and to simulate effects of treatment.

Method of displaying coronary function

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Haifa, Israel

Uri Dinnar