Oxford University Innovation Ltd

Emergent Virology LLC

United Therapeutics Corporation

The Chancellor, Masters and Scholars of the University of Oxford

Urban Ramstedt

Raymond A Dwek

Terry D Butters

Nicole Zitzmann

Brennan Klose

Kelly Lyn Warfield

Hitesh Batra

Raju A Penmasta

Anthony Treston

Tam Nguyen

Formula IA, and their use for treating viral infections. 

Iminosugars useful for the treatment of viral diseases

The present application provide novel iminosugars and their use in treatment of viral infections, such as Dengue infection and Influenza A infection. The present inventors discovered certain deoxynojirimycin derivatives may be effective against one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus. In particular, such deoxynojirimycin derivatives may be useful for treating a disease or condition caused by or associated with one or more viruses. In certain embodiments, the deoxynojirimycin derivatives may increase a survival rate or probability for a subject infected with one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus.

Deoxynojirimycin derivatives and methods of their using

Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.

Iminosugars and methods of treating viral diseases

Provided are iminosugars having antibacterial properties and methods of treating and/or preventing bacterial infections with such iminosugars. The present disclosure relates to antibacterial compounds and, in particular, to iminosugars having antibacterial activity. One embodiment is a method of treating or preventing a bacterial infection comprising administering to a subject in need thereof an antibacterial effective amount of a compound of the following formula: or a pharmaceutically acceptable salt thereof.

Antibacterial compounds

Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Togaviridae family using iminosugars, such as DNJ derivatives.

Iminosugars and methods of treating togaviral diseases

Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.

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Bethesda, MD, United States of America

Urban Ramstedt