Roche Molecular Systems, Inc.

Roche Diagnostics Gmbh

Urban Georg Schnell

Emad Sarofim

Olivier Elsenhans

Thomas Caratsch

Lukas Birrer

Karl Anton Josef Schmid

System for thermocycling of fluids in cartridges comprising a thermocycling unit in thermal contact with a first substantially planar and heat conducting wall of a cartridge, a light source for transmitting light into the interior of said cartridge through a second light transparent wall of said cartridge which is arranged substantially perpendicular to said first wall, a light detector for detecting light emerging from the interior of the cartridge through said second wall and a fluid providing unit coupled to an inlet of the cartridge for providing the cartridge with fluid and an outlet of the cartridge to drain gas when the cartridge is filled with fluid. The invention further concerns a cartridge for conducting the thermal cycling of fluids.

System for thermocycling of fluids in cartridges

A reference device for evaluating the performance of a confocal laser scan microscope. The reference device comprises a substrate () and reference fluorescing matter distributed over a surface of the substrate (). The reference fluorescing matter has a predetermined spatial distribution over the latter surface.

Reference device for evaluating the performance of a confocal laser scanning microscope, and a method and system for performing that evaluation

A quality test of fluids of biological origin can be performed optically with applying a suitable evaluation method. In case of two components to be determined in a such fluid, an extinction spectrum is approximated in a first wavelength range by a combination of a merely theoretical curve and the spectrum of the pure first substance in a first wavelength range, and this evaluation is repeated in a second wavelength range this time by approximating the measured spectrum () by a combination of a hypothetical curve, the spectrum () of the first component with the already determined concentration, and the spectrum () of the pure second component. Furthermore, it is feasible to subtract the first and second spectrum and analyze the so obtained differential spectrum () in view of anomalies. The hypothetical curves are preferably straight lines which are defined by slope and ordinate section. In the praxis of the quality test of blood, bilirubin and hemoglobin may be quantitatively be determined, whilst the background together with the lipid component can be qualitatively examined by means of the differential spectrum.

Method and apparatus for examining fluids of biological origin

A photoelectric module ( ) comprises an electrically non-conducting support ( ) and a photoelectric element including an array of spatially distributed photoelectric members applied to a surface of the support ( ). High simplicity and efficiency is obtained by the double function of module ( ) for light transmission or reflection, and spatially averaged light measurement. In a preferred application of module ( ) a light source ( , LED) is energized by a driving circuit ( ) controlled by an electronic circuit ( ). The input of this circuit ( ) is connected to the photoelectric module ( ), the power delivered to the light source ( ) and the intensity of the light beam emitted by the light source being regulated preferably to a constant value by the feedback loop consisting of module ( ), electronic circuit ( ) and driving circuit ( ).

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Muntschemier, Switzerland

Urban Georg Schnell