Life Technologies Corporation

The Johns Hopkins University

Upinder Singh

Scott Grecian

Kyle R Gee

Brian Agnew

David Raymond Graham

Shih-Jung Huang

Aleksey Rukavishnikov

Wenjun Zhou

Daniel Beacham

Scott Clarke

Michael Janes

Mahendra Rao

Uma Lakshmipathy

Rene Quintanilla

Judith Berlier

Chad Pickens

Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.

Compounds and methods for conjugation of biomolecules

Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

Anti-viral azide containing compounds

Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.

Fluorogenic pH-sensitive dyes and their methods of use (II)

The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming.

Substrates and methods for staining live stem cells

Growing community of inventors

Eugene, OR, United States of America

Upinder Singh