University of Tartu

Estonian Nanotechnology Competence Centre

Toxinvent Ou

Gelatex Technologies Oü

Tbd-biodiscovery

Uno Mäeorg

Martin Järvekülg

Ivan Ogibalov

Kristiina Ylihonko

Ilmar Kink

Ain Uustare

Valter Reedo

Ants Löhmus

Ago Rinken

Märt-Erik Martens

Andrus Tasa

Olga Tsubrik

Jukka Raunio

Tõnis Laasfeld

Jörgen Metsik

Mihkel Llisson

Maria Holmbäck

The present invention relates to novel anthracycline derivatives comprising two oxazolidine cycles and the preparation of said anthracycline derivatives. Furthermore, antibody-drug conjugates (ADCs) comprising the novel anthracycline derivatives and the use of such ADCs in the prevention and treatment of cancer are disclosed.

Antibody-drug-conjugates comprising novel anthracycline-derivatives for cancer treatment

In the current invention a method for the preparation of an oxide material was described that involves bringing the sol onto the substrate, the gelation of the solution and thermal treatment of the gel. Alkoxides are used as precursor materials for the sol preparation and substrate free structures are employed for the manufacturing of the oxide material. A gel film with thickness ranging from 5 nm to 1 &#x3bc;m is created onto the sol layer. The gelled film is separated into pieces by self organizing and the gelled part is disconnected from the substrate. Substrate free tubular structures with diameters ranging from 0.01-100 &#x3bc;m are formed of the gel film which are then heated at temperature range of 200-1600 C during a period of 5 minutes to 10 hours. The manufactured oxide materials are employed as catalysts, gas sensors, stationary phases of chromatographic columns, composite materials, thermal isolation materials and micro- or nano electronic mechanical systems (MEMS or NEMS) components.

Method for preparing oxide material

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Tartu, Estonia

Uno Mäeorg