Council of Scientific and Industrial Research

Other

Ummanni Ramesh

Prathama Satyendra Mainkar

Srivari Chandrasekhar

Togapur Pavan Kumar

Jerald Mahesh Kumar

Boggavarapu Subrahmanya Sastry

Katragadda Suresh Babu

Kanchanapally Tejaswini

Karre Nagaraju

Debabrata Mukhopadhyay

Pitchakuntla Mallesham

Mohammad Abdul Sattar

Divya Duscharla

The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R, R, R, R, Rand Rare selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.

Nimbolide analogs as anti-cancer agents and preparation thereof

The present invention provides a compound of general formulae I useful as GSK3&#x3b2; inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein

Spirooxindole compounds as GSK3B inhibitors and process for preparation thereof

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Telangana, India

Ummanni Ramesh