Eth Zurich

Eidgenossische Technische Hochschule Zurich

Umesh Ahuja

Markus Aebi

Michael T Kowarik

Karin Ilg

Saba Amber

Flavio Schwartz

Flavio Schwarz

The present invention relates tocomprising at least pgl operon ofor a functional derivative thereof and presenting at least one N-glycan ofor N-glycan derivative thereof on its cell surface and, in particular, to medical uses and pharmaceutical compositions thereof as well as methods for treating and/or preventingand optionallyinfections and methods for producing thesestrains.

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The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), nucleic acids encoding these proteins as well as corresponding vectors and host cells. In addition, the present invention is directed to the use of said proteins, nucleic acids, vectors and host cells for preparing medicaments. Furthermore, the present invention provides methods for producing said proteins.

Recombinant N-glycosylated proteins from procaryotic cells

The present invention relates tocomprising at least one pgl operon ofor a functional derivative thereof and presenting at least one N-glycan ofor N-glycan derivative thereof on its cell surface. In addition, it is directed to medical uses and pharmaceutical compositions thereof as well as methods for treating and/or preventingand optionallyinfections and methods for producing thesestrains.

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Los Angeles, CA, United States of America

Umesh Ahuja