Eniricerche S.p.a.

Consiglio Nazionale Delle Ricerche

Eni-ente Nazionale Idrocarburi

Arianna Medical Devices

Arianna Medical Devices S.r.l.

Umberto Costantino

Giulio Alberti

Piergiorgio Zappelli

Riccardo Vivani

Antonio Rossodivita

Francesco Bartoli

Antonio Calignano

Vittoria Vittoria

Luciano Bassignani

Francesco Di Gregorio

Gaetano Marenzi

Adele Bolognese

Luigi Califano

Gilberto Sammartino

The invention concerns a system for biocompatible drug release comprising: (i) a polymer matrix; (ii) an inorganic component located inside said matrix and characterized by a lamellar structure with a net positive or negative charge able to intercalate (iii) a pharmacologically active principle into said lamellar structure, by establishing an ionic type of bond with it and thereby obtaining an intercalation compound. The preparation process for the release system comprises the stages of: treating the lamellar solid in such a way as to give it a net positive or negative charge, then combining it with the chosen active principle, also in an ionic form, to obtain an intercalation compound which is then mixed with the polymer matrix. The release system can be employed in making medical devices, like sutures, membranes, osteosynthesis plaques, multilayered devices, gels and drug delivery systems.

Controlled-delivery system of pharmacologically active substances, preparation process and medical use thereof

A tetravalent metal diphosphonate-phosphite composition definable by the following general formula:

Tetravalent metal diphosphonate-phosphite composition in microporous

The present invention discloses a compound comprising a diphosphonate/phosphite of a tetravalent metal:

Mesoporous crystalline solid compound of a diphosphonate/phosphite of a

Ion exchange inorganic films made up of alpha-type or gamma-type layered structure insoluble acid salts of tetravalent metals or their salt forms, or their intercalated forms or their organic derivatives containing polar groups. A process for the preparation of said films.

Ion exchange inorganic films made up of layered structure insoluble acid

Mixed phosphorous or arsenic salts of tetravalent metals are provided having the general formula M(HAO.sub.4).sub.2-x (HAO.sub.3).sub.x.nH.sub.2 O, where M is Zr, Ti or Hf, A is phosphorus or arsenic, x is between 0.05 and 1.95, and n is 0 to 6. The salts are highly stable and have wide potential application in the fields of ion exchange, catalysis, intercalation of molecules, solid electrolytes, and chromatography. The salts are prepared by reacting a halide, oxyhalide, nitrate, sulphate, phosphate or oxide of the tetravalent metal, preferably in an aqueous medium, with at least two oxygenated acids of phosphorus and/or arsenic.

Inorganic cation exchangers and the process for their preparation

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Perugia, Italy

Umberto Costantino