UniversitÁ Degli Studi Di Genova

Biosearch Italia S.p.a.

Other

Gruppo Lepetit S.p.a.

University of Genoa

Nutravis S.r.l.

Centro Biotecnologie Avanzate

First - Societa' a Responsabilita' Limitata Con Socio Unico

Umberto Benatti

Enrico Garaci

Mauro Magnani

Antonio De Flora

Elena Zocchi

Marco Giovine

Mirko Magnone

Lucrezia Guida

Giovanna Basile

Santina Bruzzone

Luisa Franco

Gianluca Damonte

Annalisa Salis

Anna Teresa Palamara

Luigia Rossi

Enrico Millo

Orazio Taglialatela-Scafati

Sonia Scarfi′

Iliana Moreschi

Giorgio Brandi

Carlo Cerrano

Giorgio Bavestrello

Riccardo Cattaneo-Vietti

Giovanni Del Re

Ernesto Fattorusso

Sonia Scarfi'

The invention relates to the use of a very low dosage form of abscisic acid (ABA) or an in vivo hydrolysable conjugate thereof, preferably ABA-glucosyl ester (ABA-GE), for nutracentic/therapeutic use for controlling and/or preventing hyperglycaemia and weight gain in response to sugar intake with a reduction in insulin secret and an increase in muscle performance.

Treatment for improving the use of dietary sugar for energy purposes

The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD. 

Adenyl dinucleotides with antitumour activity and a method of preparing thereof

The invention relates to a novel use of fluridone&#x2014;compound known per se and used as an aquatic erbicide&#x2014;in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an inhibitor.

Fluridone as an anti-inflammatory agent

Process and apparatus for submerged biodepuration of effluents disposed of in the sea

5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthing-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.

Dinucleoside-5', 5'-pyrophosphates administered to treat HIV

Dinucleoside-5',5'-pyrophosphates

Growing community of inventors

Genoa, Italy

Umberto Benatti