Warner-lambert Company

Uma R Iyer

Isaac Ghebre-Sellassie

Mahdi B Fawzi

Majid Mahjour

Russell U Nesbitt

Robert H Gordon

Gemfibrozil formulations prepared from a single granulation of gemfibrozil and a release-control agent are disclosed. The release-control agent is present in an amount sufficient to provide both immediate and controlled release of gemfibrozil. A method of preparing the formulation and a compressed tablet are also disclosed.

Process and composition for the development of controlled release

A pharmaceutical preparation comprising drug micropellets containing a drug coated on a core material wherein each pellet ranges in size from about 70 microns to 750 microns and wherein each micropellet is coated with a controlled release coating.

Pharmaceutically useful micropellets with a drug-coated core and

A water-dispersible formulation of gemfibrozil comprising finely divided particles of pure gemfibrozil uniformly coated with a mixture of a wax and at least one hydrophilic material, the coated particles in turn being overcoated with a minor amount of a surfactant.

Water dispersible gemfibrozil compositions

A disintegratable gemfibrozil tablet providing both immediate and enteric release is compressed from a mixture of a first granulation of gemfibrozil with at least one acid-disintegratable binder and a second granulation formed from the first granulation but regranulated or coated with an alkali-disintegratable formulation of at least one substantially alkali-soluble and substantially acid-insoluble polymer.

Extended release gemfibrozil composition

The penetration of various drugs through living membranes, eg., skin, is improved by their use in topical compositions containing certain penetration-enhancer systems.

Penetration enhancement system

Sustained release solid dosage forms--i.e., tablets, pellets, granules, and powders--can be made using a combination of polymeric and ionic particulate materials to modify release profiles, permeability and processability.

Sustained release pharmaceutical preparations

A method of enhancing penetration of a drug through the skin or other biological membranes using lecithin is herein described along with pharmaceutical compositions containing effective amounts of lecithin as a penetration enhancer.

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Mendham, NJ, United States of America

Uma R Iyer