Apotex Pharmachem Inc.

Apotex Inc.

Uma Kotipalli

Yajun Zhao

Gamini Weeratunga

Allan W Rey

Daqing Che

David A Stradiotto

Sammy Chris Duncan

Peter Garth Blazecka

Craig Stewart

Bhaskar Reddy Guntoori

K S Keshava Murthy

Fan Wang

Kiran Kumar Kothakonda

Alfredo Paul Ceccarelli

Minh T N Nguyen

Murali Kondamreddy

Laura Kaye Montemayor

Ks Keshava Murthy

Kevin Wade Kells

Michael B Johansen

Kaarina K Milnes

Nalini Nagireddy

The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3) and (4) useful in the preparation of Tasimelteon (1). 

Processes for the preparation of Tasimelteon and intermediates thereof

This invention provides processes for preparation of 3-alkyl indoles of Formula 1: wherein A, Aand Aare independently selected from the group consisting of: H, X, OR, CN, CONRand C0R; Ris C-Calkyl; Ris H or C-Calkyl; Ris C-Calkyl; LG is a leaving group; X is a halogen; and n is 1, 2 or 3.

Processes for the preparation of 3-alkyl indoles

There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds. (I) 

Methods of making lubiprostone and intermediates thereof

Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications.

Atorvastatin calcium propylene glycol solvates

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Brantford, Canada

Uma Kotipalli