Solvias Ag

Altana Pharma Ag

Ulrike Nettekoven

Martin Studer

Stephan Burkhardt

Benoît Pugin

Weiping Chen

Felix Spiindler

Andreas Palmer

Abstract Compounds of the formula (I) in the form of racemates, enantiomerically pure diastereomers or a mixture of diastereomers, where the radicals Rare identical or different and are each C-C-alkyl; m is 0 or an integer from 1 to 4; n is 0 or an integer from 1 to 3; p is 0 or an integer from 1 to 5; Ris an aromatic hydrocarbon radical or a C-bonded heterohydrocarbon radical and Ris an aliphatic or C-bonded heteroaliphatic hydrocarbon radical; Rand Rare identical or different and are each an aliphatic or C-bonded heteroaliphatic hydrocarbon radical; Ris an unsubstituted or C-C-alkyl-, C-C-alkoxy- or halogen-substituted hydrocarbon radical; and A is a secondary amino group, are ligands for metal complexes which are suitable as catalysts for homogeneous enantioselective hydrogenation. 

Bis(ferrocenylphosphino) ferrocene ligands used in asymmetric hydrogenation reactions

The invention relates to compounds of the formula 1, in which R1, R2, R3, Arom and PG have the meanings as indicated in the description. These compounds are valuable intermediates for the preparation of pharmaceutically active compounds.

Intermediates for the preparation of tricyclic dihydropyrano-imidazo-pyridines derivatives

Diastereoselective hydrogenation of 1,3-hydroxyketones

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Basel, Switzerland

Ulrike Nettekoven