Boehringer Ingelheim Kg

Boehringer Ingelheim Gmbh

Ulrike Kufner-Muhl

Karl-Heinz Weber

Werner Stransky

Franz J Kuhn

Erich Lehr

Helmut Ensinger

Gunter Schingnitz

Gerhard Walther

Hubert Heuer

Franz Birke

Wolf-Dietrich Bechtel

Joachim Mierau

Enzio Muller

Gerhard Waither

Sven Luttke

Gerhard Walther, Deceased

A hetrazepine of the formula given below and a pharmaceutical composition comprising a therapeutically effective amount of the hetrazepine and a pharmaceutically acceptable inert carrier are disclosed and are useful in treating disease in a warm-blooded animal induced by endogenously formed PAF; ##STR1## wherein the substituents are defined herein.

Acylamino-substituted hetrazepines

Xanthine derivatives of formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or alkynyl, R.sub.2 is different and is alkyl, alkynyl, phenyl-alkylene, phenyl alkenylene, cycloalkyl, inter alia, R.sub.3 is cycloalkyl, phenyl, norbornane, inter alia and R.sub.4 is hydrogen, methyl, benzyl, inter alia.

Asymmetrically substituted xanthines

The present invention relates to thienodiazepines of formula Ib: ##STR1## wherein U, V, R.sub.5, R.sub.6 and R.sub.7 are as defined herein. This invention also relates to processes for preparing these thienodiazepines and their use in pharmaceutical compositions with PAF-antagonistic activity.

Hetrazepinoid amides

The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions.

Xanthine derivatives with adenosine-antagonistic activity

Bornyl xanthine derivatives with adenosine-antagonistic activity

Process for preparing xanthine derivatives, in particular

New xanthine compounds of formula I: ##STR1## wherein the substituents are defined herein, which xanthines are useful as adenosine antagonists.

8-substituted 1,3-dialiphaticxanthine derivatives

Xanthines of the formula I ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl group:

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Mainz, Germany

Ulrike Kufner-Muhl