Schering Aktiengesellschaft

Angioscore, Inc.

Invatec Technology Center Gmbh

Bayer Intellectual Property Gmbh

Other

Innora Gmbh

Bayer Pharma Aktiengesellschaft

Nexstar Pharmaceuticals, Inc.

Institut Fur Diagnostikforschung Gmbh an Der Freien Universitat Berlin

Institut Fur Diagnostikforschung Gmbh

The Spectranetics Corporation

Bayer Schering Pharma Ag

Steigerwald Arzneimittelwerk Gmbh

Schering Aktiengellschaft

Cordis Corporation

Ulrich Speck

Heinz Gries

Bruno Scheller

Hanns-Joachim Weinmann

Madeleine Caroline Berg

Wolfgang Mutzel

Heinrich Pfeiffer

Christoph-Stephan Hilger

Wolfhard Semmler

Kai Licha

Wolf-Rudiger Press

Björn Riefke

Douwe Rosenberg

Werner Krause

Peter Blaszkiewicz

Georg-Alexander Hoyer

Johannes Platzek

Ulrich Niedballa

Andreas Muhler

Franz-Josef Renneke

Thomas Balzer

Heinrich Pfeiffer, Deceased

Larry M Gold

Gabriele Schuhmann-Giampieri

Silvio Schaffner

Erich Klieger

Dieter Heldmann

Andrew Stephens

Franz-Karl Maier

Michael Bauer

Wolfgang Muetzel

Magdalena Renke-Gluszko

Bernd Raduchel

Thomas Fritzsch

Jurgen Conrad

Ludger Dinkelborg

Wolfgang Seifert

Dan J Schneider

Gabriele Schuhmann-Giampiere

Hans Peter Niendorf

Dieter Seidelmann

Bernd Raduechel

Wolfgang Ebert

Joachim Siegert

Werner Weitschies

Paul-Eberhard Schulze

Ursula Lachnit-Fixson

Friedhelm Blume

Peter Muschick

Bernd Rad&uuml;chel

Peter Henklein

Michael Stein

Georg Roessling

Hanns Joachim Weinmann

Christoph Stephan Hilger

Bj&ouml;rn Riefke

Hans-Joachim Weinmann

Heribert Miklautz

Gunnar Tepe

Wolfgang M Utzel

Bernhard Noll

Stephan Duda

Wolfram Clauss

Erwig Pinter

Johann-Diederich Hahn-Godeffroy

Hans-Martin Siefert

Madeline Caroline Berg

Bernhard Acksteiner

Dietmar Jentsch

Heidemarie Goerner

Uli Hanisch

Georg-Alexander Hayden

Norbert Hosten

Goran Lukic

Brunn Scheller

Panayiotis Roumeliotis

Sabina Hofmann

Hartmut P Scheurer

The present invention relates to a drug-eluting medical device, in particular a balloon for angioplasty catheters with drug elution to prevent the restenosis of the vessel subjected to angioplasty. More particularly, the present invention relates to a catheter balloon completely or partially coated with paclitaxel in hydrated crystalline form or in hydrated solvated crystalline form, having an immediate release and bioavailability of a therapeutically effective amount of paclitaxel at the site of intervention. The balloon can be made of a polyether-polyamide block copolymer, or a polyester amide, or polyamide-12.

Drug-eluting medical device

A balloon catheter for treating elongate diseased vessels with a variable diameter, comprising a pre-stretched balloon and a catheter shaft, which forms a wire lumen embodied to guide a guide wire and forms a liquid lumen by which a liquid can be fed to the balloon. The balloon is fastened to a first catheter shaft element at a first, proximal fastening site and fastened to a second catheter shaft element at a second, distal fastening site, wherein the second fastening site is movable along a longitudinal axis of the catheter shaft in relation to the first fastening site. The balloon surrounds a section of the catheter shaft which extends between the first and second fastening sites. Here, the section of the catheter shaft surrounded by the balloon encloses different regions of the catheter shaft with a changing longitudinal extent of the balloon.

Balloon catheter

The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.

Method of coating scoring or cutting balloon catheters

The invention relates to a drug-coated balloon catheter which has a catheter balloon mounted on its distal end and an expansion protection surrounding the same. The invention is characterized in that the catheter balloon is protected from premature expansion even under strong mechanical stress and in that the catheter balloon folds back more easily after dilation.

Controlled expansion balloon catheter

The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of the at least one drug being a limus drug and the at least one lipophilic antioxidant being butylated hydroxytoluene is excluded.

Coating formulations for scoring or cutting balloon catheters

The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.

The present invention is related to a medical device carrying at least on a portion of its surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiarectic acid, resveratrol and propyl gallate, and wherein scoring or cutting balloons as medical devices are excluded.

Formulations for drug-coated medical devices

This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.

Pharmaceutical-coated medical products, the production thereof and the use thereof

For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue.

Medical device for dispersing medicaments

Growing community of inventors

Berlin, Germany

Ulrich Speck