Bayer Aktiengesellschaft

Ulrich Schwartz

Dieter Arlt

Karl-Erwin Piejko

Rolf Grosser

Bruno Bomer

Wolfgang Arlt

Andreas Nickel

Hans-Walter Brandt

The invention relates to optically active homo- and copolymers made from optically active (meth)acrylamides, the polymers being immobilized on silica gel, a process for their preparation, and their use as adsorbents, in particular as the stationary phase for chromatographic racemate resolution.

Optically active (meth)acrylamides, a process for their preparation, and

In the chromatographic separation of a mixture of antipodes of optically active chemicals by passing a solution of such mixture over an optically active adsorbent to effect adsorption, and then eluting the adsorbed material, the improvement which comprises employing as the adsorbent particles of an optically active and cross-linked polymer containing the repeating structural unit ##STR1## in which R.sup.1 represents hydrogen or methyl, and

Optical active (meth)acrylamides and polymers thereof for racemate

Diastereomers can be separated with good industrial success with the aid of extractive distillation. The separation process is characterized in that an auxiliary which changes the partial pressure of the various diastereomers to be separated to a different degree and thus allows easier separation of the diastereomers by distillation is added during the distillation. Using the present process diastereomic cis/trans-permetric acid methyl esters and mixtures of menthol and isomenthol can be separated with isolation of 99% pure product.

Separation of diastereomers by extractive distillation

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Leverkusen, Germany

Ulrich Schwartz