Bayer Aktiengesellschaft

Ulrich Nielsch

Michael Sperzel

Hilmar Bischoff

Mazen Es-Sayed

Dirk Denzer

Graham Sturton

Rolf Henning

Peter Eckenberg

Gabriele Br&auml;unlich

Karl-Heinz Schlemmer

Ulrich E Muller

Martin Bechem

Carsten Schmeck

Klemens Lustig

Christoph Gerdes

Rudi Grutzmann

Mary F Fitzgerald

Trevor S Abram

Stephen Richard Tudhope

R&uuml;diger Fischer

Stefan Wohlfeil

Peter Kolkhof

Michael Lögers

Stefan Lohmer

J&uuml;rgen Stoltefuss

Ulrich M&uuml;ller

Rudi Gr&uuml;tzmann

Michael L&ouml;gers

Jürgen Stoltefuss

Gabriele Braunlich

Rudiger Fischer

Werner Stürmer

Burkhardt Fugmann

Gabriele Bräunlich

Werner St&uuml;rmer

The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formulawherein R, R, R, A, D, G, and E are as defined in the specification and claims, a process for preparing these materials, pharmaceutical compositions containing them, and a method for using them in the treatment of anemias.

6-carboxyphenyldihydropyridazinone derivatives and use thereof

Tetrahydroquinolinyl 6-methyldihydrothiadiazinone derivatives and use thereof

N-(3-benzofuranyl)urea-derivatives are prepared by reacting of 3-amino-substituted benzofuranes with appropriate substituted isocyanates or isothiocyanates. The N(3-benzofuranyl)urea-derivatives can be used as active ingredients in medicaments particularly for the treatment of acute and chronic inflammatory processes.

N-(3-benzofuranyl)urea-derivatives

N-(3-benzofuranyl) urea-derivatives

The new arylacetamides are obtained by first converting appropriately substituted arylacetic acids into the acetyl chlorides and then converting these into the amides using the appropriate amines. The new arylacetamides can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.

Arylacetamides and their use as medicaments

The pyrimido[1,2-a]indoles according to the invention are prepared by reacting appropriately substituted phenylacetic acid derivatives with phenylglycinols. The pyrimido[1,2-a]indoles can be used as active compounds in medicaments, in particular in medicaments with antiatherosclerotic activity.

Pyrimido[1,2-a]indoles

Heterocyclyclcarbonyl substituted benzofuranyl-ureas are prepared by reacting heterocyclylcarbonyl substituted 3-amino-benzofuranes with appropriate isocyanates or isothiocyanates. The unsubstituted ureas are transferred into substituted ureas by usual methods of substitution. The heterocyclylcarbonyl substituted benzofuranyl-ureas are useful as active ingredients in medicaments particularly for the treatment of acute and chronical inflammatory processes.

Heterocyclylcarbonyl substituted benzofuranyl-ureas

Compounds of the formula (I): ##STR1## are prepared by reaction of the phenylacetic acid derivatives substituted by the appropriate heterocycles, optionally in an activated form, with phenylglycinols. The compounds are suitable as active compounds in medicaments, in particular in medicaments having antiatherosclerotic activity.

Pyridazino-, pyrimido-, pyrazino- and triazinoindoles,

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Düsseldorf, Germany

Ulrich Nielsch