Roche Diabetes Care, Inc.

F. Hoffmann-la Roche Ag

Ulrich Mueller

Herbert Wieder

Bernd Hiller

Herbert Fink

Alexander Poggenwisch

Markus Siebenhaar

Andreas Knoerzer

Christoph Grulke

Uli Delventhal

A method for detecting in-vivo properties of a biosensor. In the inventive method, a sensitivity-to-admittance relation is provided and a raw current in the biosensor is measured. An in-vivo current response is also measured at first and second operating points. A time constant &#x3c4; is determined by the electrical capacitance C of the working electrode and the electrical resistance Rof the membrane by &#x3c4;=R&#xb7;C. The first and second operating points are selected below and above &#x3c4;, respectively. An analyte value in a sample of a body fluid is determined by using the raw current and compensating sensitivity drift in the biosensor, which in turn is compensated by using the measured value for the raw current and a corrected value for the sensitivity. The failsafe operation of the biosensor is monitored by using the in-vivo current response measured at the first and second operating points.

Method and electronics unit for detecting in-vivo properties of a biosensor

A sensor device for determining the concentration of an analyte under in-vivo conditions that includes an electrode system having an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion from the exterior of the electrode system to the immobilized enzyme molecules. The diffusion barrier may include an aliphatic polyurethane. A process of manufacturing such a sensor device is also disclosed.

Sensor device for determining the concentration of an analyte under in-vivo conditions and process of manufacturing

Growing community of inventors

Mannheim, Germany

Ulrich Mueller