University System of Maryland

Varian Medical Systems Particle Therapy Gmbh

Varian Medical Systems Particle Therapy Gmbh & Co Kg

Ulrich Langner

Byong Yong Yi

Warren D D'Souza

John Gordon Eley

Katja Langen

Per Rugaard Poulsen

Sina Mossahebi

Chaitanya Kalavagunta

Techniques are presented for optimizing a treatment plan for charged particle therapy. The method includes obtaining medical image data voxels inside a subject in a reference frame of a radiation source that emits a beam of charged particles at multiple tracks with a controlled emitted energy at each track. Hydrogen density (HD) is determined based on the medical image data. Stopping power ratio (SPR) along a first beam having a first track and first emitted energy is calculated based on HD. A range to a Bragg peak is calculated along the first beam based on the SPR and the first emitted energy. The first beam track or the first emitted energy, or both, is modified based at least in part on the beam range to determine a second track and second emitted energy. Output data that indicates the second track and second emitted energy are sent.

System and method for forming a treatment plan for charged particle therapy using hydrogen density

A method for beam therapy is provided. The method includes receiving first data indicating a plurality of target volumes within a target region inside a subject for particle beam therapy relative to a particle beam outlet on a gantry for directing a particle beam from a particle beam source. The method further includes moving automatically, one or more energy modulator components to reduce an energy of the particle beam and deliver the particle beam to the target region such that a Bragg Peak is delivered to at least one target volume of the plurality of target volumes. The method further includes repeating the moving automatically as the particle beam source rotates with the gantry around the subject, without changing the energy of the particle beam at the particle beam outlet, until every target volume is subjected to a Bragg Peak.

Techniques for particle beam therapy

The present disclosure relates to a new scan technique for particle radiation therapy that may be used for cancer treatment. One embodiment relates to a method of mitigating interplay effect in particle radiation therapy in a moving target including a period of movement, where the particle radiation therapy defines a planned dose in each spot of each layer of the moving target. The method comprising dividing the planned dose in each spot into a number of spot repaintings; and generating a scan pattern for each layer by defining a beam-on time at each spot for each spot repainting, and calculating a wait time between consecutive beam-on times to distribute the spot repaintings for each spot of a respective layer are distributed over a duration of an integer number of periods of movement.

Mitigation of interplay effect in particle radiation therapy

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Upton, MA, United States of America

Ulrich Langner