Bayer Aktiengesellschaft

Ulrich Horlein

Friedel Seuter

Horst Boshagen

Karl-August Meng, Deceased

Elisabeth Perzborn

Friedrich Hoffmeister

Otto Behner

Gerd Reinhardt

Hans Werner Schubert

An ether derivative of a dihydroxybenzene of the formula ##STR1## in which R.sup.1 is 1 to 3 identical or different substituents selected from hydrogen, halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto and carbalkoxy, with in each case 1 to 4 carbon atoms in the alkyl and alkoxy groups, and

Thrombin inhibitory new dihydroxybenzene ether derivatives

6-Substituted-1,2-benzisothiazolin-3-ones carrying an aminoalkyl group in the 2-position and being optionally substituted in the 4- and/or 5-position are antithrombotic agents. The compounds, of which 2-(2-diethylaminoethyl)-4,5-dimethyl-1,2-benzisothiazolin-3-one is a representative embodiment, can be prepared by cyclization of an appropriately substituted bis-[2-(aminoalkylcarbamyl)phenyl]disulfide, or by other disclosed methods.

Anti-thrombotic 1,2-benzisothiazolin-3-ones

1,2-Benzisothiazolin-3-ones

The invention provides novel antithrombotics diphenyl-disulphide-2,2'-bis-carboxylic acid amides of the general formula ##STR1## in which R.sup.1 represents a hydrogen or halogen atom or an optionally substituted alkyl, alkoxy or aralkoxy group,

Basically alkylated dithiosalicyclic acid amides and their use as

Benzomorphanes of the formula: ##SPC1## Wherein

Growing community of inventors

Wuppertal, Germany

Ulrich Horlein