Bayer Intellectual Property Gmbh

Bayer Pharma Aktiengesellschaft

Direvo Industrial Biotechnology Gmbh

Direvo Biotechnology Ag

Basf Se Corporation

Ulrich Haupts

Andreas Scheidig

Christian Votsmeier

Jan Tebbe

Uwe Gritzan

Michael Strerath

Ulrich Kettling

Wayne Coco

Susanne Steinig

Peter Scholz

Simone Brückner

Klaus Pellengahr

Hanna Plittersdorf

Kerstin Baral

Kornelia Kirchner

Hanna Tinel

Andreas Wilmen

Birgitta Leuthner

Christoph Freiberg

Oliver Kensch

Mark Trautwein

Lars Linden

Andre Koltermann

Wayne M Coco

Nadine Koch

Kirsten Leineweber

Ute Beister

Markus Rarbach

Ute Solloch

Christian Voetsmeier

Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNF&#x3b1;); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.

Antibodies to TNF&#x3b1;

The present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A- and B-chains are connected by a linker peptide. The invention further provides Relaxin fusion polypeptides with extended half-life. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides.

Relaxin fusion polypeptides and uses thereof

The present invention provides an insertion, deletion and/or substitution mutein of wild-type&#x3b2;-mannanase having enhanced thermostability, proteolytic stability, specific activity and/or stability at low pH, a nucleic acid molecule encoding said mannanase mutein, a composition comprising said mannanase mutein; a method for its preparation, and its use for food and feed processing, for coffee extraction and the processing of coffee waste, as a supplement to food and feed, for enzyme aided bleaching of paper pulps, as bleaching and/or desizing agent in textile industry, for oil and gas well stimulation by hydraulic fracturing, as detergent, for removal of biofilms and in delivery systems, or for the processing of renewable resources intended for the production of biological fuels.

Mannanases

The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.

Engineered enzymes and uses thereof

Growing community of inventors

Odenthal, Germany

Ulrich Haupts