T2 Biosystems, Inc.

Netbio, Inc.

Ande Corporation

Ulrich Hans Thomann

Eugene Tan

Gregory John Kellogg

Richard F Selden

John A Wright

Heung Chuan Lam

Valery Leonidovich Bogdanov

Thomas Jay Lowery, Jr

Lori Anne Neely

Rahul K Dhanda

Heidi Susanne Giese

Jessica Lee Snyder

Jessica Ann Townsend

Benjamin B Stone

Cheryl Ann Bandoski-Gralinski

Joanne Lawton Garver

Nu Ai Phung

Brendan Manning

Urvi Ved

Frédéric Sweeney

Daniella Lynn Logan

Michael Andy Pfaller

Justin Layne Black

Glenn Magnuson

William Coulter Harris

John P Mcdonough

The invention features methods, systems, and cartridges for amplification of target nucleic acids in complex samples, for example, whole blood. The invention also features diagnostic and therapeutic methods based on amplification of target nucleic acids characteristic of pathogens present in complex samples containing cells and/or cell debris, for example, whole blood.

Methods and systems for amplification in complex samples

The invention features methods panels, cartridges, and systems for detecting pathogens and for diagnosing and treating diseases, including bacteremia and sepsis.

NMR methods and systems for the rapid detection of bacteria

The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (includingspp. such as, and) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.

NMR methods and systems for the rapid detection of tick-borne pathogens

The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.

Integrated nucleic acid analysis

Integrated systems for the multiplexed amplification and detection of six and greater dye labeled fragments

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Stow, MA, United States of America

Ulrich Hans Thomann