Degussa Aktiengesellschaft

Ulrich Groeger

Karlheinz Drauz

Wolfgang Leuchtenberger

Christian Wandrey

Gunter Knaup

Rolf Wichmann

Manfred Kircher

Eberhard Breuker

G Unter Knaup

New N-acyl dipeptides and their use

N-acyl dipeptides and their compositions

A method of producing enantiomerically pure, open-chain N-alkyl-L or D amino acids which can be carried out with good yields and without excessive or expensive purification and suitable for industrial production. A racemic mixture of an open-chain N-acyl-N-alkyl amino acid is split by means of a stereospecific amino acylase coordinated with an enantiomerically pure N-acyl-N-alkyl-L or D amino acid to yield one of the antipodes to the corresponding, enantiomerically pure, open-chain N-alkyl-L or D amino acid. Then, either the remaining initial compound or the cleavage product is separated. The enantiomerically pure, open-chain N-alkyl amino acids are useful, for e.g. cyclosporins.

Method of producing enantiomerically pure, open-chain N-alkyl-L or

A microbiologically produced, thermostable N-acylproline-acylase and a process for obtaining it from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.

Method of making L-proline using an N-acyl-L-protine acylase

The invention is directed to a method of producing L-amino acids from .alpha.-ketocarboxylic acids by means of continuous fermentation with the aid of glutamate producing bacteria with biomass retention in which the cells are separated by microfiltration and/or centrifugal separators.

Method for the fermentative production of L-amino acids from

A substantially purified N-acyl-L-proline-acylase from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.

Substantially purified N-acyl-L-proline acylase from Comamonas

Growing community of inventors

Aschaffenburg, Germany

Ulrich Groeger