Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Bayer Schering Pharma Ag

Merck Serono S. A.

Ulrich Graedler

Hartmut Greiner

Guenter Hoelzemann

Christiane Amendt

Christina Esdar

Thomas Fuchss

Margarita Wucherer-Plietker

Dieter Dorsch

Norbert Beier

Santosh Shripad Kulkarni

Andreas Goutopoulos

Rolf Gericke

Thomas Maier

Meinolf Thiemann

Thomas Beckers

Matthias Schwarz

Theresa L Johnson

Renate Sekul

Bertram Cezanne

Xuliang Jiang

Catherine Jorand-LeBrun

Dirk Finsinger

Ulrich Abel

Thomas Baer

Florian Lang

Axel Becker

Josef Stadlwieser

Kerstin Otte

Thomas Ciossek

David Bruge

Holger Deppe

Michel Calderini

Djordje Musil

Armin Zuelch

Holger Kubas

Per Hillertz

Margarita Wucherer-plietker

Atropisomers, solid forms, salt forms, and deuterated derivatives of the ATM inhibitor 8-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(3-fluoro-5-methoxypyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydroimidazo[4,5-c]quinolin-2-one as well as compositions thereof are provided. The stable atropisomers do not interconvert and are represented by the following formulae.

Imidazolonylquinoline compounds and therapeutic uses thereof

The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment of cyclophilin-related disorders.

Compounds for the inhibition of cyclophilins and uses thereof

Compounds of the formula (I), in which R, R, R, R, Rand Y have the meanings indicated in Claim, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors and for the treatment of inflammatory diseases.

Aminopyridine derivatives for treating tumors and inflammatory diseases

Novel difluorophenyldiacylhydrazide derivatives of the formula I, in which R, R, R, R, R, Rand Rhave the meanings indicated in claim, are kinase inhibitors and can be used for the treatment of diseases and complaints such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in any type of fibroses, inflammatory processes, tumours and tumour diseases.

Difluorophenyldiacylhydrazide derivatives

Compounds of the formula I in which X, R, R, R, Rand Rhave the meanings indicated in Claim, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.

Pyrrolopyridinylpyrimidin-2-ylamine derivatives

Novel 5-cyanothienopyridines of the formula (I), in which R, Rand Rhave the meanings indicated in claim, are inhibitors of TGF-beta receptor kinase, and can be employed, inter alia, for the treatment of tumors.

5-cyanothienopyridines for the treatment of tumours

Novel triazole derivatives are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumours.

Triazole derivatives

The invention relates to novel pyrimidine derivatives of Formula (1) which are efficacious inhibitors of protein kinases, in particular of one or more isoforms of the protein kinase B/Akt.

4,6-disubstituted pyrimidines and their use as protein kinase inhibitors

Growing community of inventors

Heidelberg, Germany

Ulrich Graedler