Bayer Aktiengesellschaft

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Ulrich E Muller

Stefan Wohlfeil

Martin Beuck

Matthias Muller-Gliemann

Rudolf H Hanko

Thomas Kramer

Jurgen Dressel

Andreas Knorr

Stanislav Kazda

Walter Hubsch

Johannes-Peter Stasch

Peter Fey

Dirk Denzer

Hilmar Bischoff

Rudi Grutzmann

Siegfried Goldmann

Richard D Connell

Siegfried Zaiss

Ulrich Niewohner

Elisabeth Perzborn

Erwin Bischoff

Stefan Lohmer

Ozkan Yalkinoglu

Ulrich Rosentreter

Siegfried Raddatz

Michael Matzke

Claudia Hirth-Dietrich

Peter Norman

Nigel J Cuthbert

Hans-Georg Dellweg

Hilary P Francis

Joachim Hutter

Klaus-Helmut Mohrs

Volker-Bernd Fiedler

Marie G McKenniff

Horst Boshagen

Klaus Mohrs

Peter Eckenberg

Ulrich Nielsch

Anke Domdey-Bette

Rolf Hartmuth Fischer

Hans Peter Rath

Rolf Angerbauer

Winfried Joentgen

Peter Kolkhof

Matthias Schramm

Torsten Groth

Harro Traubel

Christoph Sigwart

Christoph Gerdes

James J Elting

Eugen Gehrer

Bruno Bomer, Deceased

Bernhard Beckermann

Horst Bohagen

Walter Husch

Stanisiav Kazda

Guido M Bomer, Heir

Hans-Peter Belleman

Hans-Peter Bellemann

The pyrimido[1,2-a]indoles according to the invention are prepared by reacting appropriately substituted phenylacetic acid derivatives with phenylglycinols. The pyrimido[1,2-a]indoles can be used as active compounds in medicaments, in particular in medicaments with antiatherosclerotic activity.

Pyrimido[1,2-a]indoles

The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives are suitable as active compounds in medicaments, in particular in antiarteriosclerotic medicaments.

Indolyl-substituted phenylacetic acid derivatives

The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.

Bicyclic heterocyclic compounds

Method of producing reactive halogen-free, polyisobutene

The heterocyclically substituted phenylglycinolamides are obtained by reaction of heterocyclically substituted phenylacetic acids with appropriate phenylglycinols. The heterocyclically substituted phenylglycinolamides are suitable as active compounds in medicaments, in particular in antiatherosclerotically active medicaments.

Heterocyclically substituted phenylglycinolamides

The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis.

Use of phenylcyclohexylcarboxamides

The heterocyclic aryl-, alkyl- and cycloalkylacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.

Heterocyclic aryl-, alkyl- and cycloalkylacetamides

The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.

Hetero-linked phenylglycinolamides

Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.

Trisubstituted biphenyls

Amides and sulphonamides of benzylamines having heterocyclic substituents are prepared by first converting the corresponding carboxylic acids into the corresponding amines and then substituting these on the amine nitrogen in a corresponding manner. The new amides and sulphonamides of benzylamines having heterocyclic substituents can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.

Amides and sulphonamides of benzylamines having heterocyclic substituents

Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.

Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid

Compounds of the formula (I): ##STR1## are prepared by reaction of the phenylacetic acid derivatives substituted by the appropriate heterocycles, optionally in an activated form, with phenylglycinols. The compounds are suitable as active compounds in medicaments, in particular in medicaments having antiatherosclerotic activity.

Pyridazino-, pyrimido-, pyrazino- and triazinoindoles,

The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.

Heterocyclically substituted phenylacetic acid derivatives and their use

Benzyloxy-substituted phenylglycinolamides are prepared by reaction of benzyloxy-substituted phenylacetic acids with phenylglycinols. The benzyloxy-substituted phenylglycinolamides are suitable as active compounds in medicaments, in particular in medicaments for the treatment of atherosclerosis.

Benzyloxy-substituted phenylglycinolamides

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Wuppertal, Germany

Ulrich E Muller