Bayer Aktiengesellschaft

Chinese Academy of Medical Sciences

Ulrich Benz

Bodo Junge

Thomas Glaser

Peter-Rudolf Seidel

Teunis Schuurman

Rudolf Schohe

Jorg Traber

Horst Meyer

Egbert Wehinger

Jean-Marie Viktor De Vry

Jean-Marie V De Vry

Andreas Knorr

Arno Widdig

Hans-Joachim Kabbe

Liang Huang

Geng-tao Liu

Ming-he Yang

Yen-rong Chen

J Org Traber

The method of treating stroke in a patient suffering therefrom by administering a substituted aminomethylchroman of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.

Substituted aminomethyltetralins and their heterocyclic analogues

A method of treating depression or stroke in a patient suffering therefrom by administering a substituted aminomethylchroman of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## and R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.

Method for treating depression using substituted aminomethyltetralins

For binding 5-HT.sub.1 receptors and thereby treating central nervous system disorders, novel substituted aminomethyltetralins and their heterocyclic analogues of the formula ##STR1##

For binding 5-HT.sub.1 receptors and thereby treating central nervous system disorders, novel substituted aminomethyltetralins and their heterocyclic analogues of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.

Purified Clausenamide of the formula ##STR1## is obtained by extraction of leaves of Clausena lansium followed by purification, Reduction products, ethers, etc. can be produced. The compounds are effective in treating hypoxia and amnesia.

Delta-butyrolactams, thereof, processes for the preparation thereof and

Pyridinecarboxylic acid esters of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,

Ischaemia or hypoxia controlling compositions containing

The invention relates to substituted 4-aminomethylene-chromans and chromens of Formula (I) infra, as well as methods for making of said chromans and chromens, compositions containing said chromans and chromens and methods for the use of said chromans, chromens and compositions containing said chromans and chromens. The compounds and compositions of the invention are useful for their circulation influencing activity.

Substituted 4-aminomethylene-chromans and -chromenes, processes for

A method of controlling damage to the central nervous system of a patient which comprises administering to such patient a central nervous system-controlling effective amount of a pyridine derivative of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,

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Duesseldorf, Germany

Ulrich Benz