Gambro Lundia Ab

Gambro Ab

Ulrich Bauer

Bernd Krause

Markus Storr

Reinhold J Buck

Werner Beck

Reinhold Deppisch

Arnd Wochner

Helmut Hildwein

Ruth Dietrich

Franz Baumeister

Juergen Graf

Hermann Göhl

Christian Hirssig

Karsten Villis

Katja Krämer

Hermann G&ouml;hl

Katja Kr&auml;mer

The present invention relates to a continuous process for preparing permselective hollow fiber membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood which comprises a two-stage drying and tempering treatment of the hollow fiber membranes. According to a further aspect, the invention relates to a continuous process for drying permselective hollow fiber membranes on-line. The invention also relates to devices for on-line drying of permselective hollow fiber membranes.

On-line drying of hollow fiber membranes

The present disclosure relates to devices and processes for the production of hollow fiber membrane bundles. The bundles are used for the manufacture of filtration and/or diffusion devices, e.g., capillary dialyzers.

Device and process for the manufacture of hollow fiber membrane bundles

The present disclosure relates to processes for the production of capillary dialyzers. The processes involve contact-free thermoforming of bundles of hollow fiber membranes. The present disclosure also relates to an apparatus for contact-free thermoforming of bundles of hollow fiber membranes.

Contact-free thermoforming of fiber bundles

The invention relates to processes for the production of capillary dialyzers. The processes involve thermoforming of bundles of hollow fiber membranes. The disclosure also relates to an apparatus for thermoforming bundles of hollow fiber membranes.

Thermoforming of fiber bundles

The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional &#x2014;OH end groups and reacting the &#x2014;OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with &#x2014;OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The &#x2014;OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.

Biocompatible polymer film

The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional &mdash;OH end groups and reacting the &mdash;OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with &mdash;OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The &mdash;OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.

Growing community of inventors

Hechingen, Germany

Ulrich Bauer