University of Pennsylvania

Perseptive Biosystems Inc.

Ulo Langel

James H Eberwine

Philip G Haydon

Jai-Yoon Sul

Junhyong Kim

Emelia Eiriksdottir

Tiina Peritz (nee Pajunen)

Tina Peritz

Kalle Kilk

Jennifer Zielinski

Mattias Hallbrink

Kulliki Saar

Andres Valkna

Margus Pooga

Tamas Bartfai

Kalle c/o Hultberg Kilk

The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and organisms. The present invention further provides method for the rapid sequencing of nucleic acids without using conventional sequencing techniques or reactions.

Compositions, methods and kits for real-time nucleic acid analysis in live cells

Methods of detecting transcription

The present invention includes compositions, methods and kits for the identification of a polypeptide that binds to a predetermined RNA sequence. The invention comprises, in part, a photoreactive moiety to aid in identification of such a polypeptide.

Methods and compositions for identifying RNA-binding proteins

Constructs of peptides and nucleic acid analogs conjugated together for transport across a lipid membrane and for delivery into interactive contact with intracellular polynucleotides are disclosed. Transport is effected through at least the exterior membrane of a cell, and most likely also through the walls of subcellular structures separated from the cytosol by lipid membranes, including the nucleus, mitochondria, ribosomes, etc. Peptide nucleic acid (PNA) analog sequences conjugated through a labile disulfide bond to transporting peptides, are intracellulary cleaved, and target mRNA (antigene) or dsDNA (antisense).

Membrane-permeable constructs for transport across a lipid membrane

Growing community of inventors

Bandhagen, Sweden

Ulo Langel