Tenaya Therapeutics, Inc.

Epiodyne, Inc.

Aditya Birla Chemicals (usa) LLC

Ulhas Bhatt

Julio Cesar Medina

Alok Nerurkar

Tien Widjaja

Frederick Seidl

David Sperandio

Pingyu Ding

Thomas T Nguyen

Snahel Patel

Xiaodong Wang

Jason A Duquette

Zhi-Liang Wei

Yihong Li

Mohammad A Mandegar

Stefan J Pastine

Szymon Kosinski

Martin Holan

John Lee

Heng Cheng

Corinne Sadlowski

Lawrence R McGee

Larry Mcgee

Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.

Fluoroalkyl-oxadiazoles and uses thereof

Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Opioid receptor modulators

This application relates, in part, to novel salts represented by the following structure of Formula (1): wherein Ris selected from the group consisting of hydrogen and optionally substituted alkyl (e.g., unsubstituted Calkyl, e.g., —CH); Ris optionally substituted alkyl (e.g., unsubstituted Calkyl, e.g., —CH); each occurrence of Rand Ris independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted aryl; Rand Rcan combine with each other to form optionally substituted cycloalkyl; each m and n is independently an integer ranging from 1 to 20 (e.g., m and n is independently an integer ranging from 1 to 5); and each of Qand Qis independently a counterion (e.g., each of Qand Qis independently a counterion selected from the group consisting of chloride, bromide, fluoride, iodide, acetate, carboxylate, hydrogen sulfate, nitrate, and phenolate, and sulfonate, e.g., chloride), and methods of making the same.

Salts of diaminoacetals and diaminoketals and their synthesis, and their transformations to diaminoacetals and diaminoketals

Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R, R, R, R, R, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Opioid receptor modulators and products and methods related thereto

This application relates, in part, to novel salts represented by the following structure of Formula (1): wherein Ris selected from the group consisting of hydrogen and optionally substituted alkyl (e.g., unsubstituted Calkyl, e.g., &#x2014;CH); Ris optionally substituted alkyl (e.g., unsubstituted Calkyl, e.g., &#x2014;CH); each occurrence of Rand Ris independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted aryl; Rand Rcan combine with each other to form optionally substituted cycloalkyl; each m and n is independently an integer ranging from 1 to 20 (e.g., m and n is independently an integer ranging from 1 to 5); and each of Qand Qis independently a counterion (e.g., each of Qand Qis independently a counterion selected from the group consisting of chloride, bromide, fluoride, iodide, acetate, carboxylate, hydrogen sulfate, nitrate, and phenolate, and sulfonate, e.g., chloride), and methods of making the same.

Growing community of inventors

South San Francisco, CA, United States of America

Ulhas Bhatt