Gambro Ab

Gambro Lundia Ab

Gambro Ag

Excorim Kb

Stemu Ab

Ulf T Nylen

Lars A Qvarnstrom

Lars-Ake L Larsson

Bo H Hakansson

Per-Olof Larsson

Lars-Goran Olsson

Bo G Mattiasson

Bengt G Paulsson

Lars Olof Naucler

Ingrid K Zetterstrand

Kersti B Johnson

Rolf H Wichers

Per I Wikstrom

Method and device for collection of liquid samples

Methods for coating hydrophilic gels onto the surface of solid particles are disclosed which include utilizing hydrophilic solid particles, intimately admixing these hydrophilic solid particles with a hydrophilic gel-forming substance at a temperature above the gelling temperature so as to coat the solid hydrophilic particles, and then separating these coated particles from each other and cooling them to a temperature below the gelling temperature. The use of these coated particles is also disclosed in connection with various separation processes, such as an ion exchanger, in those cases where the gel-forming substance contains charged groups, or providing the particles with suitable adsorbent groups.

Method of coating solid particles with a hydrophilic gel

A process is disclosed for the recovery of a compound, for example, a peptide-containing compound, from a solution containing contaminants through combined affinity-chromatographic purification and ultrafiltration. The process comprises contacting the solution containing the compound and impurities with a first complex of ligand bound to a carrier so as to form a second complex of the compound, the ligand and the carrier, wherein the carrier is comprised of a macromolecular solid material; subsequently splitting off of the compound from the second complex to reform the compound and first complex; and separating of the compound from the first complex. An arrangement for the recovery of a compound from such a solution containing impurities is also disclosed.

Process and an apparatus for the recovery of a compound

A method is disclosed for the recovery of a peptide-containing compound from a solution by the use of a ligand attached to a carrier which ligand is capable by biospecific affinity of fixing onto the peptide-containing compound. The carrier which, for example, may be a soluble macromolecule, e.g., cellulose or dextran, with ligand attached thereto, is utilized in dissolved form. The choice of ligand is determined by the type of peptide-containing compound for which it is to be used. Example of ligands which may be used are immunoglobulins, Fc-receptors, certain surface receptors from bacteria, e.g., protein A from S. aureus, co-factors and certain sugar-containing proteins. The ligand may be attached to the carrier by bonds of a covalent character, which may be achieved by periodate activation and subsequent coupling or by diimidazole coupling.

Method for the recovery of peptide-containing compound and means therefor

Process for treating and/or removal of substances from liquid,

An apparatus and method are provided for diluting a concentrated solution to be analyzed which includes a Y-coupling for combining a diluent and the concentrated solution to form a mixture. The mixture is then divided into first and second parts, such as by a pumping arrangement, with the second part of the mixture being proportional in quantity to the quantity of concentrated solution. The first part of the mixture is then supplied to an analytical device for analyzing the mixture. A chamber including a movable wall element is provided which divides the chamber into two subchambers. The first part of the mixture is supplied to the subchamber on one side of the movable wall element, which causes the movable wall element to force a proportional quantity of diluent out of the subchamber on the other side of the movable wall element. The dispensed diluent is then conveyed to mix with the concentrated solution.

Apparatus for diluting a concentrated solution

A method is provided for sampling and measuring the content of a low-molecular weight compound, such as glucose, cholesterol, or urea, in a complex fluid medium to be sampled, such as blood. A dialyzer is placed in contact with the complex fluid medium so that it passes through the dialyzer. One or more semipermeable membranes are disposed within the complex fluid medium to form one or more passageways for the passage of dialysis fluid, with the passageways being substantially smaller in volume than the volume of the surrounding complex fluid medium. A fractional portion of the complex fluid medium is acted on by the dialysis fluid and dialyzed so that only a fractional portion of the low-molecular weight compound diffuses into the passageways containing the dialysis fluid to produce a dialysate in the passageways. The dialysate is then measured to determine the content of the low-molecular weight compound in the complex fluid medium.

Method for sampling and measuring the content of a low-molecular weight

A method and apparatus is provided for measuring the content of a compound in a liquid medium, and which is particularly useful for measuring the concentration of a low molecular weight compound in a complex medium in which there is provided a dialyzer in contact with the complex fluid medium and through which dialysis fluid is conducted to receive by diffusion a portion of the low molecular weight compound to produce a dialysate. The dialysate with the low molecular weight commpound to be examined is first conducted through a venting device for removal of gaseous particles therefrom before conduction through a reaction chamber containing enzymes for promoting the conversion of the low molecular weight compound in the dialysate into a converted reaction product. The dialysate is then conducted from the reaction chamber to a measuring unit for measuring the concentration of the converted reaction product in the dialysate conducted from the reaction chamber, the concentration of the converted reaction product being representative of the content of the low molecular weight compound in the complex fluid medium.

Method and apparatus for the measurement of the concentration of a

A method and apparatus is provided which measures the content of a low-molecular compound, such as glucose, cholesterol, or urea, in a complex medium, such as blood. A dialyzer is placed in contact with the complex medium so that the complex medium may pass therethrough. In addition, dialysis fluid is supplied through the dialyzer to produce a dialysate having a property which can be measured. In the preferred embodiment, an enzyme is added to the dialysate to chemically react with the low-molecular compound to produce a chemical change which can be measured.

Apparatus for the measuring of the concentration of low-molecular

A method and apparatus is provided for measuring the content of a low-molecular weight compound in a complex medium which includes a dialyzer, conduits for conveying the complex medium through the dialyzer and conduits for supplying dialysis fluid to the dialyzer to receive by diffusion a portion of the low-molecular weight compound in the complex medium to produce a dialysate. Apparatus is also provided for conducting the dialysate produced from the dialyzer to a measuring unit, wherein the conducting apparatus includes a main flow line having an enzyme bed and a shunt flow line. A control device is provided for directing the flow of dialysate through the main flow line and the enzyme bed or the shunt flow line, so that the flow of dialysate bypasses the enzyme bed. Apparatus is also provided for comparing the dialysates in the main and shunt flow lines.

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Lund, Sweden

Ulf T Nylen