Merit Medical Systems, Inc.

Covidien LP

Edwards Lifesciences Iprm Ag

Other

Alveolus Inc.

Ulf R Borg

Eric K Mangiardi

Jason M Reynolds

Tony Alexander

Youzhi Li

Ulrich J Pfeiffer

Bo Chen

Lockett E Wood

Reinhold Knoll

Mark Yu-Tsu Su

Jason R Reynolds

Frederic Michard

Nader Maher Habashi

Howard N Reynolds

Christopher S Nelson

Jason Reynolds

A sensor for evaluating tissue of a subject is provided. The sensor includes a flexible spine disposable on the subject, a flexible member that includes first and second flexible member portions accommodated within the flexible spine, a light source, a detector and a rigid member. The light source is attached to the first flexible member portion and is configured to emit light toward the tissue. The detector is attached to the second flexible member portion and is configured to receive the light having reflected off the tissue. The rigid member is coupled with the first and second flexible member portions. In response to a curvature of the flexible spine, the rigid member moves the first and second flexible member portions along the flexible spine to adjust a distance between the light source and the detector.

Sensor with variable depth interrogation

According to various embodiments, a medical system and method for early detection of shock may include devices configured to provide information about multiple patient parameters. In certain embodiments, the system may receive input from a regional saturation sensor. Based on these inputs, the system may provide a diagnosis of shock and/or distinguish between various types of shock.

Regional saturation shock detection method and system

The invention relates to indicator dilution measurements of a central volume (V) with a first site of injection (S) upstream of the central volume (V) a second site of detection (S) of the diluted indicator downstream of the central volume (V), wherein a first additional volume (V) is defined between the first site (S) and the central volume (V) and a first additional branch (B) is defined between the first site (S) and the central volume (V) and wherein a second additional volume (V) is defined between the central volume (V) and the second site (S) and a second additional branch (B) is defined between the central volume (V) and the second site (S) wherein a result of central volumetric parameters are corrected for the first and second additional volumes (V, V) and/or for the first and second additional branches (B, B).

Device for indicator dilution measurements

A patient monitoring system may provide photoacoustic sensing based on an indicator dilution to determine one or more physiological parameters of a subject. The system may detect an acoustic pressure signal, which may include one or more thermo-dilution responses, one or more hemo-dilution responses, or a combination thereof. For example, a thermo-dilution indicator and/or a hemo-dilution indicator may be used to determine one or more hemodynamic parameters. In a further example, an isotonic indicator and a hypertonic indicator may be used to determine one or more hemodynamic parameters of the subject.

Methods and systems for photoacoustic monitoring using hypertonic and isotonic indicator dilutions

Methods and systems for photoacoustic monitoring using indicator dilution

The present invention, in an exemplary embodiment, provides a delivery system and novel handle configuration for the delivery system that facilitates repeatable placement of implantable devices. In particular, in optical embodiments, the handle allows for the reversible coupling of scopes directly to the handle to enhance physician control during placement. The delivery system also allows for one-handed manipulation as finger action can be used to engage and disengage the scope as well as actuate the extent of implantable device deployment. Exemplary delivery systems are flexible, durable and/or assure proper installation of one or more implantable devices in a single procedure. Moreover, the preferred embodiments of the delivery system provides for the reloading of the delivery device with additional implantable devices for additional interventional procedures, resulting in a substantially reusable delivery device.

Implantable device delivery system handle and method of use

The invention relates to a method and an apparatus for determining the systolic phase interval (SP) of an arterial pressure curve with a starting point (t) of the systolic phase interval (SP) and an end point (tN) of the systolic phase interval (SP) wherein a QT interval is defined as the start of the Q wave and the end of the T wave in the hearts electrical cycle and wherein the determination of the end point (tN) of the systolic phase interval (SP) is restricted to the measured points of arterial pressure which fulfill the condition that the difference in time between the end point (tN) to be determined of the systolic phase interval (SP) and the starting point (t) of the systolic phase interval (SP) is smaller than the QT interval.

Method and apparatus to determine the end of the systolic part of a pressure curve

The present invention, in preferred embodiments, provides delivery and deployment apparatuses for bifurcated stents capable of comfortably cradling the corina of bifurcated target tissue between the arms of the bifurcated stent as each arm of the bifurcated stent is delivered to a respective side branch. In particular, a family of apparatuses is provided that may be indicated for vascular and non-vascular intervention. Additionally, these apparatuses do not require the use of an ancillary means, such as one or more balloon catheters to achieve complete and precise deployment. In preferred embodiments, delivery and deployment devices in accordance with the present invention also provide, direct visualization, deployment safety features and enhanced physician control.

Bifurcated medical appliance delivery apparatus and method

Embodiments of the present invention are directed to devices for allowing a user to deploy a stent in an anatomical lumen of a patient. For example, one embodiment is directed to a device including a longitudinally extending inner tubular member and a longitudinally extending outer tubular member that are longitudinally and axially displaceable relative to one another. The outer tubular member includes at least one longitudinally extending channel formed between the exterior and interior diameter of the outer tubular member. In addition, the device includes a handle configured to displace the outer tubular member and inner tubular member relative to each other in response to user intervention and a stop configured to coaxially engage the handle to form a safety mechanism. Displaceability of the outer tubular member and inner tubular member relative to each other is limited by the safety mechanism to a predetermined threshold.

Medical appliance optical delivery and deployment apparatus and method

The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to compression forces. Exemplary embodiments provide a stent that is coated in a manner that limits the amount of coating surface area that is in direct contact with the target lumen. In particular, a covered stent is provided that is coated internally such that the outer scaffolding surface of the stent is raised from the outer surface of the coating. To this end, cilia function is only partially limited and mucociliary clearance is not significantly affected. Moreover, the coating itself has anti-adherent properties such that bacteria, fungi or other microbials cannot colonize the cover in particular and the stent generally.

Coated stent with geometry determinated functionality and method of making the same

The present invention provides a lumen measuring device and method that allows the user to calculate the exact length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure.

Lumen-measuring devices and method

A lumen measuring device generally includes a central member dimensioned to extend into a lumen and an elongate outer member having a flexible region configured to flex outward from the central member in response to retraction of the central member. In measuring a lumen, the flexible region is caused to contact the lumen. The lumen may be contacted by linear segments that hinge or by members that bow arcuately. A polygon, such as a triangle, may be defined by portions of the outer member and the central member. A handle assembly may be provided by which the disposition of the central member relative to the outer member may be adjusted. Indicators may be defined by the central member and outer member by which the disposition of the central member and by which the diameter of a lumen may be determined.

Lumen measuring devices and methods

The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to compression forces. Exemplary embodiments provide a stent that is covered so as to provide certain predefined characteristics. In particular, a covered stent is provided that is coated internally such that the outer scaffolding surface of the stent has enhanced friction points while the internal surface exemplifies certain characteristics.

Differential covering and coating methods

The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents generally and a biliary stent in particular where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to radial forces. An exemplary embodiment also provides a family of stents with novel interstice configurations that facilitate flexibility, durability and/or proper installation. Additionally, the biliary stent in accordance with the present invention provides enhanced flow mechanics to ensure the adequate clearance of viscid fluids such as bile.

Growing community of inventors

Cornelius, NC, United States of America

Ulf R Borg