Astra Lakemedel Aktiebolag

Aktiebolaget Astra

Ulf H Lindberg

Svante Bertil Ross

Sven O Ogren

Seth O Thorberg

Sven O Gren

Seth-Olov Thorberg

Thomas Hogberg

Bernt Sigfrid Carnmalm

Carl B Ulff

Sven Bengt Akerman

Gerd M Hallnemo

Bengt C Ulff

Sven-Ove Gren

Aralkyl esters and processes for their preparation

A method for treatment of senile dementia comprising administration to a patient of a therapeutically effective amount of a compound of the formula ##STR1## and pharmaceutically acceptable salts thereof, in which formula the groups R.sup.0 are the same or different and are selected from the group consisting of hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, and alkoxy having 1, 2 or 3 carbon atoms; R.sup.1 is hydrogen, methyl or ethyl; R.sup.2 is methyl or ethyl; R.sup.3 and R.sup.4 are the same or different and are hydrogen or an alkyl group having 1, 2 or 3 carbon atoms; and n is 0, 1 or 2.

Method for treatment of senile dementia

A compound of the general formula ##STR1## and pharmaceutically acceptable salts thereof, in which formula the groups R.sup.0 are the same or different and are selected from the group consisting of hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, and alkoxy having 1, 2 or 3 carbon atoms; R.sup.1 and R.sup.2 are methyl; R.sup.3 and R.sup.4 are the same or different and are hydrogen or an alkyl group having 1, 2 or 3 carbon atoms; and n is 0. Pharmaceutical preparations containing these compounds are useful for treatment of depressive disorders.

Compounds having antidepressive activity

A compound of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, in which formula the group R.sup.0 is selected from the group consisting of hydrogen, chlorine, bromine, methyl, trifluoromethyl and methoxy. Pharmaceutical compositions containing these compounds are useful for treatment of depressive disorders.

Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein X and Y are the same or different and each represents a hydrogen atom, a chloro or a methoxy group, n is an integer 0 or 1 and R.sup.1 and R.sup.2 are the same or different and each representing a hydrogen atom or a methyl group; processes for their preparation; pharmaceutical preparations containing at least one of these compounds and the use thereof in the treatment of depressive states.

Compounds of diphenylcyclopentylamine type and methods for their

A compound of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof, in which formula the group R.sup.o is trifluoromethyl. Pharmaceutical compositions containing these compounds are useful for treatment of depressive disorders.

Trifluoromethyl substituted compounds having antidepressive activity

A compound of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof, in which formula the group R.sup.o is selected from hydrogen, chlorine, bromine, methyl, trifluoromethyl and methoxy. Pharmaceutical compositions containing these compounds are useful for treatment of depressive disorders.

Aralkyl amides having antidepressive activity

A novel class of glycylglycine amides has been discovered having value as antiarrhythmic agents. The preferred compound of the present invention has the structural formula ##EQU1## Also included within the scope of this invention are compounds having C.sub.1 -C.sub.3 alkyl, alkoxy and halo substituents in the ortho, para or meta positions of the aromatic ring, compounds in which the phenyl group is replaced by benzyl or substituted benzyl and compounds in which the glycylglycine chain may be substituted with lower alkyl groups or may contain heterocyclic rings.

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Sodertalje, Sweden

Ulf H Lindberg